PMID: 8600366Mar 1, 1996Paper

Genotoxicity and DNA adduct formation of incense smoke condensates: comparison with environmental tobacco smoke condensates

Mutation Research
C C Chen, H Lee

Abstract

Indoor air pollution has now been recognized as a potentially important problem for public health, since people spend most of their day in closed environments. Incense burning is possibly associated with elevated risks of leukemia and brain tumor in children from the epidemiological studies. Thus, evaluation of the genotoxicity of smoke condensates from incense burning is needed. We examined the genotoxicity of incense smoke condensates (ISC) using the Ames test in S. typhimurium strains with different mutagenic specificity and level of metabolic enzyme, the SOS chromotest in E. coli PQ37, and sister chromatid exchange assay in Chinese hamster ovary cells (SCE/CHO). The genotoxicity of environmental tobacco smoke condensates (TSC) was also evaluated by the three assays to compare with the genotoxicity of ISC. ISC showed a positive response in TA98, but not in TA100. It suggested that ISC only contained frame shift mutagens. The mutagenicity of ISC in both strains of TA98NR with deficient nitroreductase and TA98/1,8-DNP6 with deficient O-acetyltransferase was markedly decreased compared to that in TA98 strain. However, the mutagenicity was enhanced in YG1024 with overexpression of O-acetyltransferase activity. Thus, nitroarenes ...Continue Reading

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Citations

Jul 10, 2007·Bulletin of Environmental Contamination and Toxicology·T T YangM Chang
Aug 21, 2002·The Science of the Total Environment·James J JetterMichael R Flynn
Jul 19, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y W ChengH Lee
Nov 10, 2011·Environmental Health Perspectives·Lap Ah TseXiao-Rong Wang
Sep 6, 2011·The Science of the Total Environment·Hsiao-Chi ChuangKelly A BéruBé
Sep 1, 2009·Environmental Toxicology and Pharmacology·Lou JianlinHe Jiliang
Feb 11, 2011·Cell Biochemistry and Function·Majed S AlokailSobhy M Yakout
Dec 2, 2004·Mutation Research·Kirsti Husgafvel-Pursiainen
Dec 2, 2004·Mutation Research·David M DeMarini
Mar 25, 2008·Chemico-biological Interactions·Panida NavasumritMathuros Ruchirawat
Aug 16, 2014·Environmental and Molecular Mutagenesis·Shao-Hua XieBo Zhang
May 18, 2016·Inhalation Toxicology·Tajamul HussainTerrance S Sumague
Jun 26, 2001·Environmental and Molecular Mutagenesis·Y W ChengH Lee
Nov 28, 2018·Toxicology Mechanisms and Methods·Tajamul HussainSalman Alrokayan
Jul 13, 2019·Scientific Reports·Yvonne VallèsRichard B Hayes
Apr 24, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Wentao LiIgnatius Tak-Sun Yu
Jul 15, 2017·International Journal of Environmental Research and Public Health·Xiuling SongHualiang Lin

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