Genotoxicity, carcinogenicity, and mode of action of the fried food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)

Environmental Health Perspectives
J H WeisburgerG M Williams

Abstract

Because mutagens typified by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) observed in cooked foods are widely consumed, detailed studies of their biochemical and biological properties including carcinogenicity are most important. IQ induces unscheduled DNA synthesis in liver cells, which when taken together with its powerful mutagenicity in the Salmonella typhimurium test system, predicts carcinogenicity. In female Sprague-Dawley rats, IQ did exhibit potent carcinogenicity for the mammary gland, the ear duct, and to a lesser extent, pancreas and bladder. Data from Japanese laboratories indicate carcinogenicity also to the intestinal tract. Thus, one of the mutagens formed during cooking is a versatile carcinogen that because of extensive human intake requires urgent exploration for specific human cancer risk.

References

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Citations

Jun 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K T Bogen
Mar 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R VikseL Klungsøyr
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J A HolmeB Trygg
Feb 1, 1997·Critical Reviews in Oncology/hematology·T Tanaka

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