PMID: 8596544Jan 1, 1996Paper

Genotoxicity evaluation of selenium sulfide in in vivo and in vivo/in vitro micronucleus and chromosome aberration assays

Mutation Research
F R MooreJ Theiss

Abstract

Selenium monosulfide (SeS) was reported to be carcinogenic to livers of male and female rats and livers and lungs of female mice. However, its genotoxicity profile in short-term assays is somewhat equivocal. A multiple endpoint/multiple tissue approach to short-term genetic toxicity testing has been developed in our laboratory. In the present paper, the effect of SeS in in vivo and in vivo/in vitro micronucleus and chromosome aberration assays in rat bone marrow and spleen are reported. In the in vivo assay, small but statistically significant increases in bone marrow micronucleated polychromatic erythrocytes (MNPCEs) were observed 24 h after treatment of rats with 50 mg/kg SeS and 48 h after treatment with 12.5 mg/kg. A significant decrease in the PCE/total erythrocyte (TE) ratio, indicative of cytotoxicity, was observed at the 50 mg/kg dose at the 24-h timepoint. In spleen, no increases in MNPCEs or decreases in the PCE/TE ratios were observed. No evidence of a significant increase in aberrations was observed in bone marrow or spleen. In the in vivo/in vitro assay, no increase in micronucleated binucleated cells or cells with aberrations was observed in SeS-treated rats. The small but statistically significant increases in MN...Continue Reading

References

Sep 1, 1991·Mutation Research·G KrishnaJ C Theiss
Jun 1, 1994·Mutation Research·M HayashiH Shimada
Jan 1, 1995·Environmental and Molecular Mutagenesis·M D Shelby, K L Witt
Jan 1, 1995·Environmental and Molecular Mutagenesis·G Krishna, J C Theiss
Jan 1, 1993·Environmental and Molecular Mutagenesis·M D ShelbyR R Tice

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Citations

Nov 14, 2000·Teratogenesis, Carcinogenesis, and Mutagenesis·L M AntunesM de Lourdes P Bianchi
Jul 23, 1999·Mutation Research·E RojasP Ostrosky-Wegman
Nov 30, 2006·International Journal of Toxicology·James C GriffithsRonan Power
May 23, 1997·Mutation Research·S BiswasA Sharma
May 2, 2006·Ecotoxicology and Environmental Safety·Mohammad Faisal SiddiquiAbsar-ul Hasnain

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