Genotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

Apr 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U K Ehmann, K T Wheeler

Reduction of glutathione levels in livers of mice treated with N,N'-bis (2-chloroethyl)-N-nitrosourea

Jan 1, 1979·Cancer Chemotherapy and Pharmacology·W R McConnellD L Hill

Mechanism of action of the nitrosoureas: formation of 1,2-(diguanosin-7-yl) ethane from the reaction of BCNU (1,3-bis-[2-chloroethyl]-1-nitrosourea) with guanosine.

Oct 12, 1979·Biochemical and Biophysical Research Communications·C T GombarD B Ludlum

A correlative study of the genetic damage induced by chemical mutagens in bone marrow and spermatogonia of mice. III. 1,3-Bis (2-chloroethyl)-3-nitrosourea (BCNU)

Jul 1, 1977·Mutation Research·A D TatesM Meijers

Detection of mutagenic activity in human urine using mutant strains of Salmonella typhimurium

Sep 1, 1976·Cancer·V MinnichS Kornfeld

Reaction of 1,3-bis(2-chloroethyl)-1-nitrosourea with synthetic polynucleotides

Dec 16, 1975·Biochemistry·D B LudlumC Fenselau

Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea

Sep 30, 1992·International Journal of Cancer. Journal International Du Cancer·M H Barcellos-HoffD F Deen

Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine

Mar 3, 1992·Biochemical Pharmacology·S L GersonJ K Willson

Mechanism of glutathione-mediated DNA damage by the antineoplastic agent 1,3-bis(2-chloroethyl)-N-nitrosourea

Jan 1, 1992·Chemical Research in Toxicology·W StahlG Eisenbrand

The Walker 256 carcinoma: a cell type inherently sensitive only to those difunctional agents that can form DNA interstrand crosslinks

Nov 1, 1991·Mutation Research·R J KnoxJ J Roberts

Metabolism of the chloroethylnitrosoureas

Jun 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A LemoineR M Ings

Dose-dependent cytotoxic and mutagenic effects of antineoplastic alkylating agents on human lymphoblastoid cells

Jan 1, 1991·Environmental and Molecular Mutagenesis·B J SandersonW D Henner

Mutagenic and recombinogenic consequences of DNA-repair inhibition during treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea in Saccharomyces cerevisiae

Aug 1, 1990·Mutation Research·L R Ferguson

Stimulation and inhibition of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced strand breaks and interstrand cross-linking in Col E1 plasmid deoxyribonucleic acid by polyamines and inorganic cations

Aug 1, 1990·Biochemical Pharmacology·K S Srivenugopal, F Ali-Osman

DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal

Nov 1, 1990·Mutation Research·D B Ludlum

Molecular dosimetry for sister-chromatid exchange induction and cytotoxicity by monofunctional and bifunctional alkylating agents

Nov 1, 1990·Mutation Research·W J Bodell

Formation of N2,3-ethanoguanine in DNA after in vitro treatment with the therapeutic agent, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea

Feb 1, 1990·Carcinogenesis·Y HabrakenD B Ludlum

Base sequence specificity of three 2-chloroethylnitrosoureas

Sep 15, 1990·Biochemical Pharmacology·W T BriscoeH E May

Nucleophilic selectivity of carcinogens as a determinant of enhanced mutational response in excision repair-defective strains in Drosophila: effects of 30 carcinogens

Nov 1, 1989·Carcinogenesis·E W Vogel

The relationship between O6-alkylguanine alkyltransferase activity and sensitivity to alkylation-induced sister chromatid exchanges in human lymphoblastoid cell lines.

Apr 1, 1989·Carcinogenesis·J L SchwartzB Strauss

Nucleophilic selectivity as a determinant of carcinogenic potency (TD50) in rodents: a comparison of mono- and bi-functional alkylating agents and vinyl chloride metabolites.

Nov 1, 1989·Mutation Research·A Barbin, H Bartsch

Genotoxic classification of anticancer drugs

Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·T S MatneyJ C Theiss

Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), streptozotocin, and mitomycin C in E. coli

Nov 1, 1986·Mutation Research·R J FramM G Marinus

Identification of specific DNA lesions induced by three classes of chloroethylating agents: chloroethylnitrosoureas, chloroethylmethanesulfonates and chloroethylimidazotetrazines

Jan 1, 1985·Pharmacology & Therapeutics·N W GibsonJ A Hartley

Influence of glutathione on the mutagenicity of 2-chloroethylnitrosoureas. Mutagenic potential of glutathione derivatives formed from 2-chloroethylnitrosoureas and glutathione

Dec 1, 1988·Mutation Research·W StahlG Eisenbrand

Mitotic crossing-over by anticancer drugs in Saccharomyces cerevisiae strain D5

Feb 1, 1988·Mutation Research·L R Ferguson, P M Turner

Different mechanisms of reversion of HPRT-deficient V79 Chinese hamster cells

Jan 1, 1988·Mutagenesis·M FoxJ Brennand

'Petite' mutagenesis by anticancer drugs in Saccharomyces cerevisiae

Apr 1, 1988·European Journal of Cancer & Clinical Oncology·L R Ferguson, P M Turner

Carcinogenic potency in rodents versus genotoxic potency in E. coli: a correlation analysis for bifunctional alkylating agents

Dec 1, 1987·Mutation Research·I Quinto, M Radman

Protection of Chinese hamster cells against the cytotoxic and mutagenic effects of alkylating agents by transfection of the Escherichia coli alkyltransferase gene and a truncated derivative.

Nov 1, 1987·Mutagenesis·M FoxG P Margison

Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis.

Jan 15, 1988·European Journal of Biochemistry·P A KarplusG E Schulz

Preferential alkylation by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) of guanines with guanines as neighboring bases in DNA

Mar 15, 1988·Biochemical Pharmacology·W T Briscoe, S P Duarte

DNA precipitation assay: a rapid and simple method for detecting DNA damage in mammalian cells

Jan 1, 1988·Environmental and Molecular Mutagenesis·P L Olive

The evaluation of biological interactions using response surface methodology

Sep 1, 1987·Cell Biology and Toxicology·R P SolanaR A Carchman

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes

Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L SamsonE A Waldstein

Inhibition of O6-alkylguanine-DNA-alkyltransferase activity potentiates cytotoxicity and induction of SCEs in human glioma cells resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea

Sep 1, 1987·Carcinogenesis·T AidaW J Bodell

Cytotoxicity and sister chromatid exchanges in 9L cells treated with monofunctional and bifunctional nitrogen mustards

Nov 1, 1987·Carcinogenesis·K Tokuda, W J Bodell

Evaluation of the interaction of three genotoxic agents in eliciting sister-chromatid exchanges using response surface methodology

Oct 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R P SolanaR A Carchman

Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea

Jun 1, 1986·Carcinogenesis·W J BodellM L Rosenblum

Evidence that O6-alkylguanine-DNA alkyltransferase becomes covalently bound to DNA containing 1,3-bis(2-chloroethyl)-1-nitrosourea-induced precursors of interstrand cross-links

Jan 30, 1987·Biochemical and Biophysical Research Communications·T P BrentJ S Remack

Relation between the changes in the structure and synthesis of DNA in the cells of mouse leukemia L1210 induced by 1-methyl-1-nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea

Feb 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·E D DurdyevaK B Gorbacheva

Theophylline release of replicon initiation inhibition by nitrosoureas correlates with the synergistic killing in L1210 leukemia in vitro

Jul 1, 1985·Mutation Research·J M Ducore, B S Rosenstein

Relationship between DNA damage and the inhibition of stem cells in murine bone marrow after single and repeated administration of BCNU and HECNU

Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·M R BergerP Bedford

Reaction of BCNU (1,3-bis (2-chloroethyl)-1-nitrosourea) with polycytidylic acid. Substitution of the cytosine ring

Feb 4, 1974·Biochemical and Biophysical Research Communications·B S KramerD B Ludlum

❮ Previous

Next ❯

Citations

Alkylator-induced DNA excision repair in human leukemia CCRF-CEM cells in vitro, measured using the single-cell gel electrophoresis (comet) assay

Dec 5, 2002·International Journal of Hematology·Takahiro YamauchiTakanori Ueda

Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea

Nov 26, 2003·Mutation Research·Bo HangB Singer

Enhanced DNA excision repair in CCRF-CEM cells resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea, quantitated using the single cell gel electrophoresis (Comet) assay

Sep 10, 2003·Biochemical Pharmacology·Takahiro YamauchiTakanori Ueda

Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis (2-chloroethyl)-1-nitrosourea

Dec 6, 2001·Mutation Research·C N SprungW J Bodell

Repair of DNA alkylation products formed in 9L cell lines treated with 1-(2-chloroethyl)-1-nitrosourea

Jan 9, 2003·Mutation Research·William J Bodell

Induction of specific-locus and dominant lethal mutations in male mice by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)

Nov 14, 1997·Mutation Research·U H EhlingA Neuhäuser-Klaus

Repair of DNA interstrand cross-links

Aug 23, 2001·Mutation Research·M L Dronkert, R Kanaar

Contributions of DNA interstrand cross-links to aging of cells and organisms.

Dec 18, 2007·Nucleic Acids Research·Johannes GrillariRegina Voglauer

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.

May 27, 2009·Nucleic Acids Research·Junhua ZhaoKaren M Vasquez

Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine

Mar 28, 2013·BMC Medicine·Crystal D HayesMadepalli K Lakshmana

Leukemia cells are sensitized to temozolomide, carmustine and melphalan by the inhibition of O(6)-methylguanine-DNA methyltransferase

Dec 2, 2015·Oncology Letters·Hajime AraiTakanori Ueda

Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity

Nov 27, 2007·Free Radical Biology & Medicine·Jinsong Zhang, Hongjuan Lu

Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals

May 9, 2007·DNA Repair·Ryan J HansenM Eileen Dolan

Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry

Jun 24, 2011·Rapid Communications in Mass Spectrometry : RCM·Baoqing BaiRugang Zhong

Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts

Sep 1, 2004·DNA Repair·Anton B GuliaevBo Hang

Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.

Jul 27, 2010·Biochemical Pharmacology·Kimiko IshiguroAlan C Sartorelli

Comparison of influence of carmustine and new proline analog of nitrosourea on antioxidant system in breast carcinoma cells (MCF-7)

Dec 10, 2009·Drug and Chemical Toxicology·Anna Stankiewicz-KrancElzbieta Skrzydlewska

DNA interstrand cross-link repair in Saccharomyces cerevisiae

Nov 14, 2006·FEMS Microbiology Reviews·Peter LehoczkýMiroslav Chovanec

Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway.

Apr 21, 2016·Cellular and Molecular Life Sciences : CMLS·David Lopez-MartinezMartin A Cohn

Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB

Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lauren E FrickJohn M Essigmann

The Fanconi anemia pathway and ICL repair: implications for cancer therapy

Sep 3, 2010·Critical Reviews in Biochemistry and Molecular Biology·Lily C Wang, Jean Gautier

Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles

Jan 27, 2009·Technology in Cancer Research & Treatment·ChunSheng KangJing Sheng

NBGNU: a hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance

Dec 19, 2018·Future Medicinal Chemistry·Yao GeRugang Zhong

Proline analogue of nitrosourea as a new cytotoxic prodrug

Oct 27, 2009·Archiv der Pharmazie·Anna Stankiewicz-KrancElzbieta Skrzydlewska

1-beta-D-arabinofuranosylcytosine is cytotoxic in quiescent normal lymphocytes undergoing DNA excision repair

Dec 24, 2002·Japanese Journal of Cancer Research : Gann·Takahiro YamauchiTakanori Ueda

Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance

Apr 24, 2008·Molecular Pharmacology·Takahiro YamauchiTakanori Ueda

Escherichia coli FPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells

Dec 14, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ying-Hui HeWilliam J Martin

Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry

Feb 6, 2014·Rapid Communications in Mass Spectrometry : RCM·Lili LiRugang Zhong

iRGD-mediated core-shell nanoparticles loading carmustine and O6 -benzylguanine for glioma therapy

Sep 21, 2016·Journal of Drug Targeting·Chang LiuYanyan Jiang

Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

Apr 17, 2019·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Yoko YamadaTomoe Negishi

A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents

Jan 30, 2007·Molecular Cancer Research : MCR·Daniel R McNeill, David M Wilson

Effect of cations on the formation of DNA alkylation products in DNA reacted with 1-(2-Chloroethyl)-1-nitrosourea

Oct 20, 1999·Chemical Research in Toxicology·W J Bodell

❮ Previous

Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.