PMID: 8600368Mar 1, 1996Paper

Genotoxicity of aloeemodin in vitro and in vivo

Mutation Research
A HeidemannU Mengs

Abstract

The present in vitro and in vivo experiments were undertaken to clarify the genotoxic potential of the hydroxyanthrachinone aloeemodin which can be found in different plant derived products for therapy of constipation. The results demonstrate that aloeemodin is able to induce mutagenic effects in vitro. Positive results were obtained in the chromosomal aberration assay with CHO cells, as well as in the Salmonella reverse mutation assay (frameshift mutations in strains TA 1537, TA 1538 and TA 98). No mutagenic potential of aloeemodin, however, was observed in the gene mutation assay with mammalian cells in vitro (HPRT assay in V79 cells). Each assay was performed in the presence and absence of an extrinsic metabolic activation system (S9-mix). In in vivo studies (micronucleus assay in bone marrow cells of NMRI mice; chromosome aberration assay in bone marrow cells of Wistar rats; mouse spot text [DBA/2JxNMRI]) no indication of a mutagenic activity of aloeemodin was found. Information about a possible reaction of aloeemodin with DNA was derived from an in vivo UDS assay. Hepatocytes of aloeemodin-treated male Wistar rats did not show DNA damage via repair synthesis. All these data suggest that aloeemodin is able to interact with ...Continue Reading

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Citations

Sep 6, 2001·Diseases of the Colon and Rectum·J H Xing, E E Soffer
Jan 11, 2003·Free Radical Biology & Medicine·Wayne G WamerDaniel E Falvey
Dec 11, 1997·Mutation Research·U MengsW Völkner
Oct 16, 1999·Mutation Research·U MengsW Völkner
May 19, 2010·Mutagenesis·Giovanni BrambillaAntonietta Martelli
Jan 23, 2002·The American Journal of Dermatopathology·Lina WassermanEyal Fenig
Jun 30, 2009·Mutation Research·Fabrice NesslanyDaniel Marzin
Jan 21, 2012·Journal of Food Science·Miyuki TanakaKeiji Iwatsuki
Mar 18, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Xiaoqing Guo, Nan Mei
Oct 25, 2014·Journal of Toxicology and Environmental Health. Part a·Seung Jun KwackByung-Mu Lee
Aug 9, 2011·Regulatory Toxicology and Pharmacology : RTP·Barry LynchAshley Roberts
Apr 9, 2014·The American Journal of Chinese Medicine·Ruie ChenYitao Wang
Feb 17, 2001·Journal of Applied Toxicology : JAT·S J KennelW H Griest
Dec 21, 2005·Contact Dermatitis·N ReiderB M Hausen
Oct 6, 2006·Medicinal Research Reviews·Qing HuangChoon Nam Ong
Jan 23, 2018·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Matthew Wright
Mar 17, 2007·Molecular Cancer Therapeutics·Akihiro MutoTadashi Yoshida
Nov 23, 2020·Regulatory Toxicology and Pharmacology : RTP·Alessandra BaldiMaria Daglia
Nov 1, 2014·Toxicology Research·Xiaoqing GuoNan Mei
Jun 2, 2021·Regulatory Toxicology and Pharmacology : RTP·Corrado L GalliMarina Marinovich
Jun 3, 2021·Marine Drugs·Giulia GrecoCarmela Fimognari
Jul 13, 2021·Biotechnology and Bioengineering·Bolong LiFantao Kong
May 23, 2001·Journal of Agricultural and Food Chemistry·C H WuG C Yen

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