PMID: 9639689Jun 26, 1998Paper

Genotoxicity of nitric oxide produced from sodium nitroprusside

Mutation Research
W LinZ Zhou

Abstract

Induction of mutation and micronucleus (MN) formation by nitric oxide (NO) was investigated in mammalian cells using sodium nitroprusside (SNP) as a drug donor of NO. Results showed that the concentration of NO2- in the tested solution rose according to time- and concentration-exposure to SNP. The treatment of SNP (0.5-8 micromol/ml with S9 or 2-8 micromol/ml without S9) induced a concentration-dependent increase in the mutation frequency at the gpt gene locus in g12 cells and caused a 13- (-S9) to 25- (+S9) fold increase above the background level at the highest concentration. A statistically significant increase in the number of micronucleated binucleated cells (MNBN) was also observed in treated groups. MNBN per thousand, MN per thousand and the proportion of the multiple micronuleated cells increased in a concentration-dependent manner in the concentration range of SNP (0.5-4 micromol/ml with S9 or 2-8 micromol/ml without S9). Our results indicate that SNP, an NO releasing drug, is genotoxic in g12 cells.

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Citations

Aug 24, 2006·Apoptosis : an International Journal on Programmed Cell Death·Gabriella Argentin, Rosadele Cicchetti
Oct 22, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gow-Chin Yen, Hsi-Huai Lai
Dec 3, 2015·Cellular and Molecular Neurobiology·Judit VargaJózsef Szeberényi
Feb 26, 2011·The International Journal of Neuroscience·Sankar Surendran, Maheep Bhatnagar
Oct 6, 2000·Nitric Oxide : Biology and Chemistry·H C Birnboim, H Privora
Apr 8, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jean Leandro Dos SantosMan Chin Chung
Oct 22, 1998·American Journal of Medical Genetics·G NeriA Lin

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