Genotoxicity of selected pesticides in the mouse bone-marrow micronucleus test and in the sister-chromatid exchange test with human lymphocytes in vitro

Toxicology Letters
S KevekordesH Dunkelberg

Abstract

Selected pesticides (aldicarb, 1,3-dichloropropene, methidathion, parathion, triadimefon, vinclozolin) were tested for their clastogenic and aneugenic activities in the mouse bone-marrow micronucleus (MN) test in vivo and for their sister-chromatid exchange-inducing activities in human lymphocytes in vitro in the presence and absence of an exogenous metabolizing system from rat-liver S9. 1,3-Dichloropropene significantly increased the frequencies of micronucleated polychromatic erythrocytes (PCE) in bone-marrow cells of female mice from 3.3 MN/1000 PCE to 15.3 MN/1000 PCE (187 mg per kg body weight). 1,3-Dichloropropene (100 microM) induced 16.0 SCE/metaphase after 24 h of incubation as compared with the basal rate of 11.2 SCE/metaphase (-S9) and of 15.4 SCE/metaphase as compared with 10.5 SCE/metaphase of the control (+S9). These values were statistically significantly different from each other. The other pesticides tested did neither increase the rate of micronuclei significantly in polychromatic erythrocytes in male nor in female animals. Aldicarb and methidathion induced a significant increase in SCEs in human lymphocytes in vitro only without the metabolic activating system: aldicarb, 5 microM, 24 h incubation: 15.5 SCE/me...Continue Reading

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Citations

Jan 13, 2010·Mutagenesis·Jeffrey A Ross, Sharon A Leavitt
Jun 13, 1998·Occupational and Environmental Medicine·S KevekordesH Dunkelberg
Dec 15, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Patrícia Rosa de OliveiraMaria Izabel Camargo Mathias
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May 14, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Takeshi MoritaMasamitsu Honma
Apr 30, 2009·Environmental and Molecular Mutagenesis·Aurora E Rojas-GarcíaPatricia Ostrosky-Wegman
Jul 28, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Takeshi MoritaLeonard Schechtman
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Dec 24, 2018·Ecotoxicology and Environmental Safety·Mónica AquilinoJosé-Luis Martínez-Guitarte

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