PMID: 11774363Jan 5, 2002Paper

Genotoxicity of some sulfur dyes on tadpoles (Rana hexadactyla) measured using the comet assay

Environmental and Molecular Mutagenesis
P RajaguruK Kalaiselvi

Abstract

This report presents the results of a genotoxicity study to evaluate the DNA damage caused by four sulfur dyes used in the textile and tannery industries. Alkaline single-cell gel electrophoresis assay (SCGE) was performed on erythrocytes from Rana hexadactyla tadpoles following whole-body exposure to increasing concentrations of the dyes. The dyes, along with their active ingredients, were Sandopel Basic Black BHLN, Negrosine, Dermapel Black FNI, and Turquoise Blue. The dye-treated tadpoles showed significant DNA damage, measured as mean DNA length:width ratio, when compared with unexposed control animals. Among the four tested dyes Sandopel Basic Black BHLN appears to be highly genotoxic, Dermapel Black FNI was least genotoxic, and Negrosine and Turquoise Blue were moderately toxic to R. hexadactyla tadpoles. The tadpoles showed a significant reduction in DNA damage when placed in dechlorinated tap water after exposure for a 24-hr period to the dye solutions.

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Citations

Apr 23, 2008·Cell Biology and Toxicology·Alok DhawanDevendra Parmar
Jul 18, 2012·Environmental Science and Pollution Research International·Abbas GüngördüMurat Ozmen
Aug 13, 2015·Environmental Toxicology and Chemistry·Gisele Augusto Rodrigues de OliveiraDanielle Palma de Oliveira
Apr 29, 2008·Mutation Research·G FrenzilliB P Lyons
Apr 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua MaXiaojun Peng

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