PMID: 8598834Feb 29, 1996Paper

Genotoxicity of vanadium pentoxide evaluate by the single cell gel electrophoresis assay in human lymphocytes

Mutation Research
E RojasP Ostrosky-Wegman

Abstract

Vanadium compounds are extensively used in modern industry and occupational exposure to high doses of Vanadium is quite common. In this study, the genotoxicity of vanadium pentoxide (V2O5) was evaluated directly in whole blood leukocytes and in human lymphocyte cultures using the single-cell gel electrophoresis assay (Comet Assay) to detect DNA damage expressed as DNA strand breaks and alkali labile sites. This chemical produces a clear dose-response in DNA migration in whole blood leukocytes and a significative positive effect only with the highest tested concentration in human lymphocyte cultures. After different recovery times the level of DNA damage returned to the control values. These results indicate that V2O5 is capable to induce DNA single-strand breaks and/or alkali-labile damage.

References

Jun 18, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·G L NiederP A Culp
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I R GibbonsW J Tang
Nov 1, 1978·The Journal of Cell Biology·W Z Cande, S M Wolniak
Jan 1, 1991·Teratogenesis, Carcinogenesis, and Mutagenesis·A GalliG Bronzetti
Jan 1, 1991·Mutation Research·N P SinghE L Schneider
May 1, 1990·Mutagenesis·G BronzettiA Galli
Feb 1, 1990·Toxicology Letters·J Owusu-YawC I Wei
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Sep 1, 1987·Toxicology and Industrial Health·R P SharmaS G Oberg
Oct 3, 1983·Life Sciences·B S Jandhyala, G J Hom
Aug 14, 1980·Biochimica Et Biophysica Acta·G H Bond, P M Hudgins
Oct 30, 1981·Biochemical and Biophysical Research Communications·G Carpenter
Aug 1, 1984·Environmental Research·L J Schiff, J A Graham
Oct 1, 1983·Journal of Toxicology and Environmental Health·E SabbioniA Brazzelli
Feb 1, 1980·Mutation Research·N KanematsuT Kada
Jan 1, 1980·Archives of Environmental Contamination and Toxicology·R D ParkerS G Oberg
Apr 1, 1994·Mutation Research·B Z ZhongT Ong

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Citations

Jul 16, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·M Altamirano-LozanoE Rojas
Jul 1, 1997·Environmental Health and Preventive Medicine·Y LuK Morimoto
Aug 21, 2003·Toxicology Letters·Juan José Rodríguez-MercadoMario Altamirano-Lozano
Mar 6, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·E RojasM Valverde
Jun 7, 2002·Critical Reviews in Oncology/hematology·Angelos M Evangelou
Feb 19, 1999·Mutation Research·P López-OrtalM C Gutiérrez-Ruiz
Jul 23, 1999·Mutation Research·E RojasP Ostrosky-Wegman
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Farida Louise Assem, Leonard Stephen Levy
Dec 17, 2008·Environmental Health Perspectives·Veronika A EhrlichSiegfried Knasmüller
Jul 15, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ana L Di VirgilioSusana B Etcheverry
Jan 25, 2012·Journal of Toxicologic Pathology·Detlef SchulerDouglas McGregor
Nov 1, 2008·Environmental Toxicology and Pharmacology·Fatime Geyikoglu, Hasan Turkez
Sep 13, 2008·Journal of Applied Toxicology : JAT·Ksenija DurgoJasna Franekić Colić
Apr 27, 2013·Journal of Applied Toxicology : JAT·Marcela Rojas-LemusTeresa I Fortoul
Jun 26, 1999·Journal of Toxicology. Clinical Toxicology·D G Barceloux
Dec 17, 2009·Drug and Chemical Toxicology·Juan J Rodríguez-MercadoMario A Altamirano-Lozano
Oct 24, 2013·Toxicology Mechanisms and Methods·Iwona Zwolak
Aug 2, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Juan J Rodríguez-MercadoMario A Altamirano-Lozano
Dec 2, 2014·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Kirandeep Kaur, Arvinder Kaur
Dec 13, 2016·Drug and Chemical Toxicology·Rodrigo Anibal Mateos-NavaMario Agustín Altamirano-Lozano
Sep 30, 2004·Journal of Cardiovascular Pharmacology·Masahiro SuganoNaoki Makino
Mar 1, 2016·Chemical Society Reviews·Zhongying WangRobert Hurt
Apr 21, 2019·Scientific Reports·Cristina A MatzenbacherThales R O de Freitas

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