PMID: 7529357Jan 1, 1995Paper

Genotoxicity testing of five compounds in three Drosophila short-term somatic assays

Mutation Research
M Batiste-AlentornR Marcos

Abstract

To provide further background data for the somatic mutation and/or recombination tests in Drosophila melanogaster, we have evaluated the response in 3 assays (zeste-white, white-ivory and wing spot) of 5 chemicals classified by the U.S. National Toxicology Program (NTP) as genotoxic non-carcinogens (or ambiguous). The selected compounds were 2-chloromethylpyridine, 1-nitronaphthalene, 4-nitro-o-phenylenediamine, 3-nitropropionic acid and p-phenylenediamine. Our results show that all the compounds tested produce significant increases in the frequency of mutant clones, in at least one of the assays, p-phenylenediamine being the compound which presents a clearer mutagenic activity, and the wing spot test, the assay that detects more genotoxic compounds (4/5).

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Citations

Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yannick AuclairElliot A Drobetsky
Dec 21, 2006·Toxicologic Pathology·Alan M JeffreyGary M Williams
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·S E AndrewF R Jirik
Oct 9, 2003·The Journal of Biological Chemistry·Reshmi A RambaratsinghPatricia S Lorenzo
Apr 24, 2010·The Journal of Biological Chemistry·Ruifeng GuoDavid G Johnson

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