Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey

Cell Biochemistry and Function
Ali SazciIhsan Kara

Abstract

The polymorphic methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms C677T and A1298C cause mild hyperhomocysteinemia, not only in homozygotes for C677T, but also in compound heterozygotes for C677T/A1298C. The aim of this study was to determine allelic frequencies of the polymorphic MTHFR gene C677T, A1298C. In this regard, we have investigated the allelic frequencies of C677T and A1298C polymorphisms of the MTHFR gene in 1684 randomized individuals around Turkey. DNA samples isolated from peripheral blood samples of randomized individuals were analysed. The study population consisted of 1004 females and 680 males. The frequency in Turkey of the C677T was 42.9 %; of C677C, 47.4 %; and of T677T, 9.6 %. The frequency in Turkey of A1298C was 43.7 %; of A1298A, 46.3 %; and of C1298C, 10.0 %. The allelic frequencies of the T allele of MTHFR 677 and the C allele of MTHFR 1298 were 33.34 and 33.16 %, respectively. The frequency of C677T/A1298C compound heterozygosity is highest in Turkey (21.6 %), as compared to Canada (15 %), the United States (17 %) and The Netherlands (20 %).

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Citations

Apr 1, 2008·Genetic Testing·Amira S SabbaghRami A R Mahfouz
Dec 17, 2008·Genetic Testing·Argyri GialerakiAnthi Travlou
May 10, 2008·Digestive Diseases and Sciences·Ali SazciSadettin Hulagu
Jun 28, 2008·Blood Cells, Molecules & Diseases·Avshalom Zoossmann-DiskinDavid Turner
Jan 30, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Onur TuranAtila Akkoçlu
Jun 18, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Habib GhaznaviMohammad S Soltanpour
Dec 22, 2007·Cell Biochemistry and Function·Renfang MaoSongbin Fu
Oct 11, 2014·International Journal of Vascular Medicine·Nazmiye Selçuk KapısızHasan Fahri Kapısız
Feb 18, 2003·Journal of the American Dietetic Association·Setareh Torabian EsfahaniMarie A Caudill
Apr 26, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sibel KabukcuErol Atalay
Oct 25, 2017·Indian Journal of Clinical Biochemistry : IJCB·Upendra YadavVandana Rai
Jul 1, 2020·Journal of Pediatric Hematology/oncology·Zeliha GuzelkucukNese Yarali
Nov 23, 2018·International Journal of Biological Macromolecules·M C Ergoren, P Tulay

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