DOI: 10.1101/493387Dec 11, 2018Paper

Genotype and dose-frequency may critically determine the therapeutic efficacy of chronic oxytocin treatment in humans

BioRxiv : the Preprint Server for Biology
Juan KouKeith M Kendrick


Chronic intranasal oxytocin administration daily is increasingly proposed as a therapy for social dysfunction but some clinical trials have reported small or no beneficial outcomes. No empirical evidence proves that this is optimal therapeutically or whether oxytocin receptor genotype influences treatment sensitivity. In a randomized, placebo-controlled pre-registered trial on 138 adult male subjects we investigated effects of single and repeated oxytocin treatment (24IU daily or alternatively days for 5 days). Primary neural outcomes assessed core therapeutic mechanisms of action, i.e. amygdala fear reactivity and amygdala-prefrontal intrinsic functional connectivity and modulation by oxytocin receptor polymorphisms (rs53576, rs2254298). The expected oxytocin-induced reduction in amygdala fear reactivity and associated anxious-arousal following single-dose administration was abolished after daily treatment but maintained when administered every other day. Oxytocin selectively reduced amygdala and arousal fear reactivity in AA homozygotes of rs53576 and A+ carriers of rs2254298. By contrast, oxytocin-enhanced intrinsic amygdala-prefrontal coupling was maintained independent of dose frequency and genotype. Together the findings ...Continue Reading

Related Concepts

Administration, Intranasal
Amygdaloid Structure
Clinical Trials
Fear (Mental Process)
Oxytocin Receptor

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