Genotype and phenotype correlations in diabetic patients in Uruguay

Genetics and Molecular Research : GMR
A MimbacasG Javiel

Abstract

To differentiate among different types of diabetes is becoming an increasingly challenging task. We investigated whether the patient's genetic profile is useful to identify the particular type of diabetes, to determine the corresponding hyperglycemia pathogenesis and treat accordingly. Three hundred and thirty-eight diabetic patients, diagnosed according to American Diabetes Association criteria, were recruited from 2004 to 2008 in diabetes health reference centers. We analyzed the major gene for type 1 diabetes susceptibility (HLA DQ/DR). In order to improve our understanding of the pathogenesis of the resulting hyperglycemia and to implement a more adequate treatment for the patients, we reclassified our sample according to the presence or absence of the genetic markers. We found that a higher percentage of people than expected have immunological disease, independent of their phenotype, with a relative risk of 4.62 (95% confidence interval). This methodology allowed us to establish an association between the genotype and its resulting phenotype. We found significant differences; the phenotypic classification did not reflect immunological disease based on genotype. Moreover, when we examined markers, body mass index and age of...Continue Reading

Citations

Aug 15, 2015·Journal of Diabetes Research·Matias FabregatAdriana Mimbacas
Sep 27, 2018·World Journal of Diabetes·Carolina BelosoAdriana Mimbacas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Cui-Cui WangJian-Xiang Wang
European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
I KockumA Lernmark
Hypertension Research : Official Journal of the Japanese Society of Hypertension
Hiroyasu UedaJunichi Yoshikawa
Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Michael H WilsonChristopher P Wild
© 2022 Meta ULC. All rights reserved