PMID: 11922913Mar 30, 2002Paper

Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

Cardiovascular Research
Mark A VickersBernard Keavney

Abstract

Baseline concentrations of plasma C-reactive protein (CRP) are associated with coronary heart disease. Interleukin-6 (IL-6) regulates CRP gene expression; a promoter polymorphism (-174G/C) of the IL-6 gene has been shown to influence IL-6 transcription but the relationship between genotype at this polymorphism and circulating levels of inflammatory markers remains unclear. We hypothesised that plasma CRP would be a heritable phenotype that would be influenced by genotype at this polymorphism. We measured baseline plasma CRP and determined genotypes at the -174G/C polymorphism of the IL-6 gene in 588 members of 98 nuclear families. The heritability of plasma CRP and the association of plasma CRP with genotype were determined using variance components methods. Baseline CRP levels were highly heritable (h(2)=0.39, P<0.0000001). Presence of the -174C allele was associated with higher baseline CRP levels, both in the whole population (P=0.01), and in the founders only (n=128, P=0.001). Family-based analyses confirmed the association (P=0.02) suggesting that it arises from chromosomal proximity or identity of the typed polymorphism with a genetic variant influencing baseline CRP levels. Baseline plasma CRP is a significantly heritabl...Continue Reading

Citations

Oct 7, 2004·Aging Clinical and Experimental Research·Giovanni Mario PesCalogero Caruso
May 29, 2007·Human Genetics·Ulrich BroeckelHeribert Schunkert
Jul 16, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Brankica Spasojević-DimitrijevaMirjana Kostić
Feb 8, 2003·Current Atherosclerosis Reports·Edward T H Yeh, Robert P Palusinski
Apr 7, 2005·Current Atherosclerosis Reports·François Cambien
Feb 5, 2008·Current Atherosclerosis Reports·Jacqueline Suk Danik, Paul M Ridker
Jan 2, 2013·Indian Journal of Clinical Biochemistry : IJCB·Kavita ShaliaPurvi Bhatt
Mar 24, 2004·Experimental Gerontology·Helle BruunsgaardBente Klarlund Pedersen
May 8, 2004·Experimental Gerontology·Karen Suárez KrabbeHelle Bruunsgaard
Mar 1, 2012·Genetic Testing and Molecular Biomarkers·Baddela M V Srikanth BabuAkka Jyothy
Apr 8, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sendogan AkerKatrin Ivens
May 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion VerduijnOlivier Devuyst
Aug 19, 2003·Shock·Fernando A Rivera-ChavezGrant E O'Keefe
Aug 16, 2006·Annals of Human Genetics·Piotr KozlowskiDavid J Kwiatkowski
Oct 19, 2006·Annals of Human Genetics·Leslie A LangeDonald W Bowden
Aug 19, 2011·Veterinary Clinical Pathology·Valerie M WongMarion L Jackson
Jan 2, 2003·Postgraduate Medical Journal·P J Sheridan, D C Crossman
Jan 29, 2011·Comparative and Functional Genomics·Wei Gu, Jianxin Jiang
Jul 28, 2005·Journal of Biomedicine & Biotechnology·Jonathan D Wren, Harold R Garner
Feb 16, 2005·Human Heredity·Lyle G BestJean W Maccluer
Jul 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Thomas O ObisesanJames M Hagberg
Apr 26, 2008·Stroke; a Journal of Cerebral Circulation·Myriam FornageW T Longstreth
Feb 5, 2011·Annals of Surgical Oncology·Shung-Haur YangJen-Kou Lin
Sep 6, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sadahiko Iwamoto
Sep 6, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki SaijoReiko Kishi
May 8, 2009·PloS One·Camilla Noelle RathckeHenrik Vestergaard
Dec 17, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Jennifer JonesWilliam J Sandborn

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