Genotype-Based Epigenetic Differences in Monozygotic Twins Discordant for Positive Antithyroglobulin Autoantibodies

Thyroid : Official Journal of the American Thyroid Association
Mikio WatanabeOsaka Twin Research Group

Abstract

Background: Epigenetic factors associated with the development of autoimmune diseases are unclear. Monozygotic twin pairs discordant for positive antithyroglobulin autoantibodies (TgAb) are useful to examine the epigenetic factors because of their identical genetic background. This study aimed to clarify the discordant epigenetic differences affecting the development of TgAb. Methods: Subjects were selected from 257 Japanese monozygotic twins, recruited from the registry established by the Center for Twin Research at Osaka University. TgAb positive concordant (PC) pairs were 5.7% (four pairs) and 9.6% (18 pairs) of male and female pairs, respectively. TgAb discordant (DC) pairs were 11.4% (eight pairs) and 8.0% (15 pairs) of male and female pairs, respectively. TgAb negative concordant (NC) pairs were 78.6% (55 pairs) of male pairs and 74.3% (139 pairs) of female pairs. To perform stricter grouping, the cut-off value for positive TgAb was set to 50.0 IU/mL (TgAb negative: <28.0 IU/mL; TgAb positive: ≥50.0 IU/mL; TgAb borderline: ≥28.0 IU/mL and <50.0 IU/mL). Nineteen discordant (6 male and 13 female pairs) and 185 concordant pairs (48 male and 137 female pairs) for TgAb positivity were finally examined. DNA methylation level...Continue Reading

References

Jan 22, 2003·European Journal of Endocrinology·Anthony P Weetman
Dec 29, 2006·Annals of the New York Academy of Sciences·Agathocles Tsatsoulis
Feb 27, 2007·Cell·Peter A Jones, Stephen B Baylin
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller
Aug 15, 2009·Thyroid : Official Journal of the American Thyroid Association·Kanji KasagiYoichiro Izumi
Jul 2, 2010·Biological Research for Nursing·Jacquelyn Y TaylorSharon L R Kardia
Dec 1, 2011·Epigenomics·Sarah DedeurwaerderFrançois Fuks
Dec 16, 2011·Clinical Endocrinology·Thomas Heiberg Brix, Laszlo Hegedüs
Jan 10, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Kazuo HayakawaUNKNOWN Osaka Twin Research Group
Mar 27, 2013·Nature Reviews. Endocrinology·Matthew J Simmonds
Nov 12, 2013·Journal of Autoimmunity·Mihaela StefanYaron Tomer
Jan 28, 2014·Annual Review of Pathology·Yaron Tomer
Apr 9, 2014·Journal of Neuropathology and Experimental Neurology·Katherine G MeilleurCarsten G Bönnemann
Aug 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mihaela StefanYaron Tomer
Oct 7, 2014·Clinical and Experimental Medicine·Cheng-Li LiuHong-Yi Zhang

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Citations

Jan 9, 2020·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Chika HondaNorio Sakai

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Methods Mentioned

BETA
Assay
genotyping

Software Mentioned

R
Ruby
Genome Studio

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