Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression

Biological Psychiatry
Joseph F CubellsJoel Gelernter

Abstract

Plasma activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to norepinephrine, is reportedly lower in patients with unipolar major depression with psychotic features (UDPF) than in those with nonpsychotic unipolar major depression (UD). Plasma DbetaH is under genetic control by the structural locus encoding DbetaH protein, DBH. This study tested the hypothesis that diagnosis-specific allelic variation at DBH accounts for lower plasma DbetaH in UDPF. Plasma DbetaH activity was measured in samples from patients with UDPF (n = 33) and UD (n = 45). Genotypes were determined at several functional DBH polymorphisms, including C-1021T, a single nucleotide polymorphism (SNP) in the proximal 5' region that associates with variation in plasma DbetaH activity. Mean plasma DbetaH activity was significantly lower in UDPF than in UD. Genotyping at DBH did not reveal genetic associations distinguishing UDPF from UD. A two-way analysis of variance showed significant effects of genotype and diagnostic group but no significant interaction. Although the effects of the diagnosis of UDPF, and of DBH allele status, on plasma DbetaH activity were replicated, the lower plasma DbetaH in patients with UDPF was not accounted ...Continue Reading

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Citations

Jul 21, 2005·European Archives of Psychiatry and Clinical Neuroscience·Maria Teresa M V FreireClaiton H D Bau
Jul 3, 2013·Asian Journal of Psychiatry·Massimiliano BuoliAlfredo Carlo Altamura
Apr 26, 2007·European Journal of Human Genetics : EJHG·Yi-lang TangJoseph F Cubells
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