Genotype-controlled analysis of serum dopamine β-hydroxylase activity in civilian post-traumatic stress disorder.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Yi-Lang TangJoseph F Cubells

Abstract

Norepinephrine (NE) plays a central role in post-traumatic stress disorder (PTSD). Dopamine β-hydroxylase (DβH) converts dopamine (DA) to NE and its activity varies widely across individuals. Mustapic et al. (2007) reported a PTSD-associated deficit in serum DβH activity in a genotype-controlled analysis of combat veterans. We tested whether such a deficit would occur in a sample of civilians. The severity of current adult PTSD symptoms and current DSM-IV diagnosis of PTSD were determined by the PTSD Symptom Scale (PSS). Adulthood trauma exposure was assessed using the Traumatic Experience Inventory (TEI). Serum DβH activity (sDβH) was assayed by HPLC with electrochemical detection and genotypes were determined using the Taqman® platform. Two hundred and twenty seven African American (AA) subjects were enrolled in this study, with a mean age (±SD) of 42.9 (±12.9) years. We found a strong association between rs1611115 genotype and sDβH (p<0.0001). After controlling for adulthood trauma exposure, there were no significant differences of sDβH between subjects who met a PTSD diagnosis and those who did not (p>0.05) in any genotype group. No significant correlations were found between sDβH and PTSD severity, but sDβH significantly a...Continue Reading

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Citations

Oct 25, 2011·Development and Psychopathology·Theodore P BeauchaineNatalia Potapova
Oct 10, 2013·The International Journal of Neuropsychopharmacology·Lynn M AlmliKerry J Ressler
Sep 29, 2015·Experimental Neurobiology·Hee Jin KangIn Kyoon Lyoo
Oct 16, 2019·Journal of Neurochemistry·Eugene Gonzalez-Lopez, Kent E Vrana
Sep 26, 2020·Military Medicine·Michael R HossackAdam M Willis

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