PMID: 2498923Jan 1, 1989Paper

Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse

Psychopharmacology
S Cabib, S Puglisi-Allegra

Abstract

The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the same strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.

Citations

Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·R J RodgersJ C Cole
Aug 28, 1995·Psychiatry Research·J B Lohr, M P Caligiuri
Apr 1, 1997·Progress in Neurobiology·S Puglisi-Allegra, S Cabib
Aug 24, 1999·Journal of Advanced Nursing·J LegrisG Browne

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