Genotype Distribution and Molecular Epidemiology of Hepatitis C Virus in Hubei, Central China

PloS One
Jing PengZiyong Sun

Abstract

Little is known about the molecular epidemiology of hepatitis C virus (HCV) infection in Central China. A total of 570 patients from Hubei Province in central China were enrolled. These patients were tested positive for HCV antibody prior to blood transfusion. Among them, 177 were characterized by partial NS5B and/or Core-E1 sequences and classified into five subtypes: 1b, 83.0% (147/177); 2a, 13.0% (23/177); 3b, 2.3% (4/177); 6a, 1.1% (2/177); 3a, 0.6% (1/177). Analysis of genotype-associated risk factors revealed that paid blood donation and transfusion before 1997 were strongly associated with subtypes 1b and 2a, while some subtype 2a cases were also found in individuals with high risk sexual behaviors; subtypes 3b, 6a, and 3a were detected only in intravenous drug users. Phylogeographic analyses based on the coalescent datasets demonstrated that 1b, 2a, 3b, and 6a were locally epidemic in Hubei Province. Among them, subtype 1b Hubei strains may have served as the origins of this subtype in China, and 2a and 3b Hubei strains may have descended from the northwest and southwest of China, respectively, while 6a Hubei strains may have been imported from the central south and southwest. The results suggest that the migration patt...Continue Reading

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Citations

Mar 24, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yih-Ing HserAmit Chakrabarti
Nov 23, 2017·Frontiers in Microbiology·Joseph Torresi
Sep 25, 2020·Journal of the International AIDS Society·Chin Pok ChanShui Shan Lee
Feb 23, 2020·Virologica Sinica·Xin-Cheng QinYong-Zhen Zhang

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Methods Mentioned

BETA
genotyping
Assay
PCR

Software Mentioned

jModeltest
Figtree
Tracer
BioEdit
TreeAnnotator
CLUSTAL
BEAST
PhyML

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