Genotype-phenotype correlation between the cardiac myosin binding protein C mutation A31P and hypertrophic cardiomyopathy in a cohort of Maine Coon cats: a longitudinal study

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
S GranströmJ Koch

Abstract

A missense mutation (A31P) in the cardiac myosin binding protein C gene has been associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats. The aim of this study was to investigate the effect of A31P on development of HCM, myocardial diastolic dysfunction detected by color tissue Doppler imaging and occurrence of cardiac death during longitudinal follow-up in a cohort of Maine Coon cats. The original cohort comprised 282 cats (158 of wild-type genotype, 99 heterozygous for A31P and 25 homozygous for A31P). Prospective longitudinal study including echocardiography and registration of survival. The median age at the initial examination was 1.7 years (range, 0.8-9.2 years) and 6.4% (18/282) of the cats were diagnosed with HCM. One hundred sixty-five cats were eligible for echocardiographic re-examination, and during an average follow-up period of 2.7 years an additional 6.7% (11/165) of the cats developed HCM. Survival data could be obtained for 262 of the cats originally included, and among these 9.2% (24/262) died of causes that met the study criteria for cardiac death. In the homozygous group 80% (20/25) of cats included were diagnosed with HCM and 48% (12/25) suffered cardiac death during follow-up. These results co...Continue Reading

References

May 1, 1993·Journal of Veterinary Internal Medicine·E N PetersonM R Slater
Jul 20, 2002·Journal of the American Veterinary Medical Association·John E RushDonald J Brown
Dec 28, 2002·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Kerstin HanssonPeter Lord
Feb 5, 2003·Journal of Veterinary Internal Medicine·Karen M PedersenAnnette K Ersbøll
May 27, 2003·Journal of Feline Medicine and Surgery·L FerasinP R Wotton
Nov 3, 2004·Journal of the American College of Cardiology·Sara L Van DriestMichael J Ackerman
May 17, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Valerie ChetboulJean-Louis Pouchelon
Oct 27, 2006·Journal of Veterinary Internal Medicine·Carolina Carlos SampedranoRenaud Tissier
Mar 9, 2007·Schweizer Archiv für Tierheilkunde·S C RiesenC Amberger
May 24, 2008·Journal of Veterinary Internal Medicine·R FriesK M Meurs
Nov 6, 2010·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Jérôme MaryAnne Thomas
Jul 9, 2011·Journal of Veterinary Internal Medicine·S GranströmJ Koch
Jun 8, 2014·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Kieran BorgeatDavid J Connolly

❮ Previous
Next ❯

Citations

Oct 11, 2017·The Journal of Veterinary Medical Science·Schober KarstenYildiz Vedat
Apr 18, 2019·Journal of Veterinary Internal Medicine·Ilaria SpallaVirginia Luis Fuentes
Jul 19, 2019·Journal of Veterinary Internal Medicine·Kerry A LoughranMarc S Kraus
Mar 28, 2020·Clinical Genetics·Cristina Gil-OrtuñoMaría J Fernández Del Palacio
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.