Genotype-phenotype correlation in long QT syndrome

Global Cardiology Science & Practice
Shankar Baskar, Peter F Aziz

Abstract

Congenital long QT syndrome, caused by a cardiac channelopathy, is a leading cause of sudden cardiac death in the young population. In total, 16 genes have been implicated in this condition, with three genes being the most commonly affected. Long QT syndrome is one of the earliest conditions for which a genotype specific treatment was designed. This genotype-phenotype correlation extends to involve the clinical presentation, electrocardiographic manifestation and treatment strategies. It is necessary for the clinician treating these patients to be cognizant of the important role played by the genotype in order to best provide counseling and treatment options to this unique population.

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Citations

Feb 16, 2016·Genomics, Proteomics & Bioinformatics·Jessica D Tenenbaum
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Aug 16, 2017·Journal of Biomedical Science·Simona MagiSanto Gratteri
Sep 10, 2020·Annals of the New York Academy of Sciences·Khalil SaadehKamalan Jeevaratnam

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