Abstract
This study sought to determine the relationship between long QT syndrome (LQTS) subtype (LTQ1, LTQ2, LTQ3) and postnatal cardiac events (CEs). LQTS presenting with 2:1 atrioventricular block or torsades de pointes in the fetus and/or neonate has been associated with risk for major CEs, but overall outcomes and predictors remain unknown. A retrospective study involving 25 international centers evaluated the course of fetuses/newborns diagnosed with congenital LQTS and either 2:1 atrioventricular block or torsades de pointes. The primary outcomes were age at first CE after dismissal from the newborn hospitalization and death and/or cardiac transplantation during follow-up. CE was defined as aborted cardiac arrest, appropriate shock from implantable cardioverter-defibrillator, or sudden cardiac death. A total of 84 fetuses and/or neonates were identified with LQTS (12 as LQT1, 35 as LQT2, 37 as LQT3). Median gestational age at delivery was 37 weeks (interquartile range: 35 to 39 weeks) and age at hospital discharge was 3 weeks (interquartile range: 2 to 5 weeks). Fetal demise occurred in 2 and pre-discharge death in 1. Over a median of 5.2 years, there were 1 LQT1, 3 LQT2, and 23 LQT3 CEs (13 aborted cardiac arrests, 5 sudden card...Continue Reading
References
Jul 1, 1991·European Heart Journal·N SaoudiP Touboul
Nov 1, 1995·American Heart Journal·D L TrippelP C Gillette
Jun 1, 1993·Circulation·A GarsonG W Vick
Dec 3, 1998·Journal of Cardiovascular Electrophysiology·A P GorgelsZ Al Halees
Nov 17, 2001·JAMA : the Journal of the American Medical Association·M J AckermanJ A Towbin
Mar 20, 1965·Lancet·C ROMANO
Mar 5, 2004·Journal of the American College of Cardiology·Jean-Marc LupoglazoffPascale Guicheney
Jun 9, 2004·Circulation·Todd E MillerNanette H Bishopric
Jan 11, 2007·Circulation·Marianne ArnestadPeter J Schwartz
Jan 6, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Peter J SchwartzLia Crotti
Oct 21, 2009·Circulation·Peter J SchwartzCarla Spazzolini
Dec 10, 2009·Circulation. Arrhythmia and Electrophysiology·Hitoshi HorigomeMinoru Horie
Mar 4, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Peter F AzizMaully J Shah
Apr 11, 2013·JAMA : the Journal of the American Medical Association·Lia CrottiMichael J Ackerman
Sep 3, 2013·Circulation. Arrhythmia and Electrophysiology·Bettina F CuneoD Woodrow Benson
Apr 16, 2014·Epilepsia·Robert S FisherSamuel Wiebe
Mar 6, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sue RichardsUNKNOWN ACMG Laboratory Quality Assurance Committee
Aug 7, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joseph W RossanoUNKNOWN International Society for Heart and Lung Transplantation
Sep 28, 2017·HeartRhythm Case Reports·Benjamin A BlaisJeremy P Moore
Jun 7, 2019·European Heart Journal·Lia CrottiPeter J Schwartz
May 19, 2020·Circulation. Arrhythmia and Electrophysiology·Sarah StrandRonald T Wakai
Citations
Aug 8, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·UNKNOWN Writing Committee MembersPhilip L Wackel
Aug 2, 2021·Indian Pacing and Electrophysiology Journal·UNKNOWN Writing Committee MembersUNKNOWN Document Reviewers
Aug 3, 2021·Cardiology in the Young·Maully J ShahUNKNOWN Document Reviewers: Philip M. Chang, Fabrizio Drago, Anne M. Dubin, Susan P. Etheridge, Apichai Kongpatanayothin, Jose Manue