Genotype prevalence, viral load and outcome of hepatitis B virus precore mutant infection in stable patients and in patients after liver transplantation

Clinical Transplantation
Ziv Ben-AriDaniel Shouval

Abstract

The precore mutant is detectable in most Israeli patients with persistent hepatitis B virus (HBV) infection. The aim of this study was to determine the prevalence of HBV genotypes, viral load and outcome of precore mutant infection in stable patients and in patients after liver transplantation. The prevalence of HBV genotype and viral load were investigated in 81 patients with HBV precore mutant infection. Of these, 50 patients (40 males, 10 females; mean age 43.4 +/- 11.0 yr) underwent liver transplantation and were serum HBV DNA-negative by hybridization at the time of transplantation. Patients received long-term HBV immunoprophylaxis and immunosuppression, and lamivudine in cases of graft HBV recurrence. The remaining 31 patients were stable, with serum anti-HBe-positivity. Genotypes were tested by restriction fragment length polymorphism of an S gene amplicon. Precore mutations were studied with an INNO-LiPA probe assay. Follow-up was 46.6 +/- 37.7 months. Most of the transplanted group was of Middle Eastern origin (53.6%); the remainder were from Eastern Europe (21.4%), Western Europe and the USA (10.8%), Africa (7.1%), and Asia (7.1%). In the transplanted group, the pre-transplant HBV genotype D was the most prevalent (96...Continue Reading

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Citations

Oct 14, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Shu-Hong YiGui-Hua Chen
Nov 15, 2006·Clinical Transplantation·Christoph EisenbachJens Encke
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Xiao XuShusen Zheng
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Aug 3, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Bassem S S GuirgisHassan M E Azzazy
Oct 24, 2014·World Journal of Gastroenterology : WJG·Tahereh GhazianiHerbert L Bonkovsky

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