Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity

Biogerontology
Craig S WildingE Janet Tawn

Abstract

The comparison of genotype frequencies between neonates and elderly populations can aid in the identification of loci, and polymorphisms within those loci, that affect longevity. Here we have compared genotype frequencies of seven polymorphisms at four loci involved in DNA repair between a cohort of newborns (n = 290) and a retired population (average age at sampling 70.02 years; n = 430) who have suffered a lifetime of DNA damage from normal, metabolic processes, and on whom selection on DNA repair gene variants may be expected to have acted. No differences in genotype frequencies at the four SNP loci were seen, indicating that there is no evidence of association with longevity in this population. Significant differences in frequency of certain repeat sizes at three microsatellite loci were detected. However, since there is no known functional consequence of these repeat lengths, the action of selection cannot yet be ascribed.

References

Aug 1, 1994·Mutation Research·C M KingY A Barnett
Oct 1, 1995·Mutation Research·M AkiyamaN Nakamura
May 20, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M L MuirasA Bürkle
Jun 4, 1998·Journal of Medical Genetics·D S ChaseJ Burn
Jan 15, 1999·European Journal of Human Genetics : EJHG·G De BenedictisC Franceschi
Feb 3, 1999·Annals of the New York Academy of Sciences·A Morley
Feb 25, 2000·Mutation Research·J Vijg
Feb 26, 2000·Carcinogenesis·L J Marnett
Nov 30, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F CottetM L Muiras
Feb 13, 2001·Biochemical and Biophysical Research Communications·E TaioliS Garte
Mar 29, 2001·Trends in Genetics : TIG·L J Marnett, J P Plastaras
May 12, 2001·Mechanisms of Ageing and Development·G De BenedictisA I Yashin
May 18, 2001·Nature·J H Hoeijmakers
Nov 13, 2002·Mutation Research·Cindy C Ruttan, Barry W Glickman
Mar 1, 2003·Science·Paul HastyJan Vijg
Sep 27, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Gu ZhuNicholas G Martin
Nov 26, 2003·Mutation Research·Geir SlupphaugHans E Krokan
Mar 31, 2004·Experimental Gerontology·Simona NeriErminia Mariani
Mar 31, 2004·Experimental Gerontology·Svetlana KrichevskyArie Ben Yehuda
Jun 5, 2004·Toxicology Letters·Beate PeschYon-Dschun Ko
Aug 21, 2004·International Journal of Epidemiology·Sarah J Lewis, Eric J Brunner
Oct 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lene ChristiansenKaare Christensen
Nov 18, 2004·Biogerontology·B BessenyeiI Semsei
Jul 16, 2005·International Journal of Radiation Biology·C A WhitehouseJ Fomina

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Citations

Nov 14, 2008·Gene Therapy·S I S Rattan, R Singh
Nov 4, 2008·Carcinogenesis·Scott MaynardVilhelm A Bohr
Mar 30, 2019·Acta Veterinaria Hungarica·Anna ValkóÁdám Dán

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