PMID: 9525600Apr 3, 1998Paper

Genotype-specific complementation of hepatitis delta virus RNA replication by hepatitis delta antigen

Journal of Virology
J L Casey, J L Gerin

Abstract

Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same genotype. The significance of the sequence differences has been unclear but could be responsible for pathogenic variations associated with the different genotypes. Studies of the mechanisms of HDV replication have been limited to cDNA clones from HDV genotype I, which is the most common. To perform a comparative analysis of HDV RNA replication in genotypes I and III, we have obtained a full-length cDNA clone from an HDV genotype III isolate. In transfected Huh-7 cells, the functional roles of the two forms of the viral protein, hepatitis delta antigen (HDAg), in HDV RNA replication are similar for both genotypes I and III; the short form is required for RNA replication, while the long form inhibits replication. For both genotypes, HDAg was able to support replication of RNAs of the same genotype that were mutated so as to be defective for HDAg production. Surprisingly, however, neither genotype I nor genotype III HDAg was able to support replication of such mutated RNAs of the other genotype....Continue Reading

References

Jan 1, 1992·Methods in Enzymology·B R Cullen, M H Malim
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L CaseyJ L Gerin
Mar 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BoninoJ L Gerin
Sep 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Rizzetto
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·J E RozzelleS M Lemon
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L CaseyJ L Gerin
May 1, 1993·Journal of Virology·D W Lazinski, J M Taylor
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G A NiroJ L Casey

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Citations

Oct 17, 2001·The Journal of General Virology·V IvaniushinaP Dény
Aug 5, 2003·The Journal of Clinical Investigation·Bruno B BordierJeffrey S Glenn
Mar 3, 2004·Journal of Virology·Sheng-Chieh HsuWan-Jr Syu
Mar 29, 2000·Critical Reviews in Clinical Laboratory Sciences·L E Modahl, M M Lai
Sep 20, 2002·Journal of Virology·Bruno B BordierJeffrey S Glenn
Aug 22, 2001·The Journal of General Virology·T NakanoB H Robertson
Dec 16, 2004·Journal of Molecular Evolution·Maria Anisimova, Ziheng Yang
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sheng-Chieh HsuJaw-Ching Wu
May 4, 2020·Antiviral Research·Julie Lucifora, Marion Delphin
Jul 9, 2021·Frontiers in Microbiology·Hans J NetterLilly K W Yuen
Jul 27, 2021·Frontiers in Microbiology·Katja GierschMaura Dandri

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