Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection.

Journal of Clinical Microbiology
Jia-Horng KaoDing-Shinn Chen

Abstract

Genotype C of hepatitis B virus (HBV) has been shown to be associated with a poor clinical outcome, compared to genotype B. To explore the clinical phenotypes, with special reference to the seroconversion of hepatitis B e antigen (HBeAg) and frequency of acute exacerbation between patients infected with HBV genotypes B and C, a cohort of 272 Taiwanese patients with chronic HBV infection was analyzed. According to the status of HBeAg at enrollment and frequency of acute exacerbation during the follow-up period, five groups of patients with distinct clinical phenotypes were categorized. Of the 272 HBV carriers, 185 (68%) were infected with HBV genotype B and the remaining 87 (32%) were infected with genotype C. Among them, 150 (55%) were positive for HBeAg and patients with genotype C infection tended to have a higher positive rate of HBeAg than those with genotype B infection (63 versus 51%). Genotype B was more prevalent than genotype C in different groups of HBV carriers. However, the prevalence of genotype C in patients with multiple episodes of acute exacerbation who failed to have HBeAg seroconversion was significantly higher than in all 272 patients (50 versus 32%, P = 0.025), in those with HBeAg seroconversion after only ...Continue Reading

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Jan 5, 2002·Journal of Clinical Microbiology·Jia-Horng KaoDing-Shinn Chen

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Citations

Dec 7, 2007·Journal of Biomedical Science·Chih-Lin Lin, Jia-Horng Kao
Jul 21, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qiaoxia TongDuande Luo
Nov 1, 2002·Current Treatment Options in Gastroenterology·Raymond S. Koff
Sep 10, 2010·Hepatology International·Myron John TongLawrence Mitchell Blatt
Nov 11, 2010·Hepatology International·Shu-Fen LiuWan-Long Chuang
Apr 10, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kenji AbeVasily F Uchaikin
Aug 2, 2003·Gastroenterology·Chi-Jen ChuAnna S F Lok
Feb 20, 2003·Journal of Hepatology·Hari S Conjeevaram, Anna Suk-Fong Lok
Jul 20, 2002·The Lancet Infectious Diseases·Jia-Horng Kao, Ding-Shinn Chen
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jin-De ChenDing-Shinn Chen
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeTeresa L Wright
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