Abstract
This study was designed to describe the frequencies of multiple myocardial infarction (MI) risk-associated genotypes among different racial groups. Racial disparities in the prevalence of cardiovascular disease (CVD) are well known. Recent large Japanese case-control studies identified connexin-37 (GJA-4), plasminogen activator inhibitor-1 (PAI-1), and stromelysin-1 (MMP-3) polymorphisms as risk factors for MI, but the prevalence of these genotypes among different racial groups in the U.S. needs to be determined. Genomic deoxyribonucleic acid from 95 healthy African Americans (AA) and 95 healthy European Americans (EA) was used for genotyping. Deoxyribonucleic acid containing the region of interest was amplified using the polymerase chain reaction, followed by genotyping using pyrosequencing. All three MI-risk genotypes were observed in both populations and were in Hardy-Weinberg equilibrium. The frequencies of two of the three "risk-associated" genotypes were significantly higher in the AA population: GJA4 C1019T T/T: AA, 20%, EA, 7% (p = 0.053); MMP3 -1171delA A/A: AA, 78%, EA, 24% (p < 0.001); PAI-1 -668delG G/G: AA, 55%, EA, 16% (p < 0.001). The likelihood of two or more high-risk genotypes was 3.3% among EA subjects and 51...Continue Reading
References
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·P ErikssonA Hamsten
May 31, 1996·The Journal of Biological Chemistry·S YeA M Henney
Aug 14, 1999·Journal of Internal Medicine·M BoermaI A Cotgreave
Apr 13, 2000·The New England Journal of Medicine·J G CantoN W Weissman
Jan 5, 2002·Journal of the American College of Cardiology·Peter A McCulloughUNKNOWN Resource Utilization Among Congestive Heart Failure (REACH) Study
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Tanja RundekRalph L Sacco
Dec 13, 2002·The New England Journal of Medicine·Yoshiji YamadaMitsuhiro Yokota
Apr 30, 2003·Circulation·Andreas FestaSteven M Haffner
Jul 4, 2003·The New England Journal of Medicine·Elizabeth G Nabel
Oct 18, 2003·Journal of the American College of Cardiology·Akihiro HirashikiMitsuhiro Yokota
Citations
Mar 7, 2007·Cardiovascular Drugs and Therapy·David E LanfearHoward L McLeod
Nov 2, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea FlexRoberto Pola
Jul 21, 2011·Circulation. Cardiovascular Quality and Outcomes·Suzanne V ArnoldUNKNOWN Cardiovascular Outcomes Research Consortium
Aug 18, 2009·BMC Genetics·Josiemer MatteiJose M Ordovas
Jul 14, 2007·BMC Genetics·Iftikhar J Kullo, Keyue Ding
Jan 5, 2014·PloS One·Zelda de LangeMarlien Pieters
Feb 3, 2016·Translational Stroke Research·Hilda AhnstedtMarilyn J Cipolla
Feb 28, 2006·Journal of Cardiac Failure·Bodh I Jugdutt
Aug 28, 2007·American Heart Journal·David E LanfearHoward L McLeod
May 16, 2013·Stroke; a Journal of Cerebral Circulation·Pitchaiah MandavaThomas A Kent
Dec 15, 2007·Molecular Nutrition & Food Research·Marlien Pieters, Hester H Vorster
Apr 30, 2005·Current Opinion in Cardiology·Anne M Deschamps, Francis G Spinale
Jun 9, 2005·Journal of Hypertension·Peter Bolli
Jun 27, 2014·Canadian Review of Sociology = Revue Canadienne De Sociologie·Lorenzo FrangiVincenzo Memoli
Dec 24, 2015·Spine·Timothy Y WangOren N Gottfried
Dec 8, 2009·Annals of Human Biology·Irene M PredazziGiuseppe Novelli
Oct 4, 2018·Medicine·Haoming HuangZhongqi Yang