Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner

Metabolism: Clinical and Experimental
Nunzio BottiniF Gloria-Bottini

Abstract

We investigated the possible role of cytosolic low-molecular-weight protein-tyrosine-phosphatase (cLMWPTP or acid phosphatase locus 1 [ACP1]) in the mediation of age at onset of type 1 diabetes. ACP1 is an enzyme involved in signal transduction of T-cell receptors, insulin, and other growth factor receptors. We studied acid phosphatase polymorphism in 189 consecutive children with type 1 diabetes admitted to the Pediatric Clinic of Sassari University (Sardinia) and in 86 adolescent patients with recently diagnosed type 1 diabetes from continental Italy. In both populations, females with medium-high activity acid phosphatase genotypes had onset of disease significantly earlier than males. The data suggest that acid phosphatase genotype affects the age of onset and probably also the sex ratio in type 1 diabetes. Sex hormones might modulate the susceptibility to autoimmune diseases, including type 1 diabetes, through the influence of signal transduction pathways involved in immune functions. Elucidation of the molecular basis for gender differences in the course and severity of type 1 diabetes could have important implications for treatment as well, because there might be gender-specific effects in the response to immunotherapy.

Citations

Dec 9, 2004·Diabetes/metabolism Research and Reviews·N BottiniE Bottini
Nov 16, 2007·International Journal of Immunogenetics·C NielsenS T Lillevang
May 29, 2008·Human Biology·Fulvia Gloria-BottiniEgidio Bottini
Aug 21, 2013·Human Biology·Nazzareno LucariniFulvia Gloria
May 20, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·P SaccucciF Gloria-Bottini
Jun 7, 2011·Genetics and Molecular Research : GMR·V PolzonettiN Lucarini
Jul 29, 2015·Archives of Gynecology and Obstetrics·Fulvia Gloria-BottiniEgidio Bottini
Sep 16, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Nunzio BottiniEgidio Bottini
Oct 15, 2005·International Archives of Allergy and Immunology·N BottiniE Bottini
Jul 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Yu-Hsiang ShuRichard M Watanabe
Feb 8, 2007·International Archives of Allergy and Immunology·F Gloria-BottiniE Bottini
Jul 1, 2005·Metabolism: Clinical and Experimental·Umberto IannacconeFulvia Gloria-Bottini
May 21, 2008·Fertility and Sterility·Maria AmmendolaFulvia Gloria-Bottini
Feb 17, 2009·Metabolism: Clinical and Experimental·Antonino De LorenzoEgidio Bottini

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