Genotypic analysis of sequential genital herpes simplex virus type 1 (HSV-1) isolates of patients with recurrent HSV-1 associated genital herpes

Journal of Medical Virology
R Wim RoestAlbert D M E Osterhaus

Abstract

Clinical recurrences of Herpes simplex virus type 1 (HSV-1)-associated genital herpes are thought to be caused by reactivation of latent endogenous HSV-1. However, the possibility of reinfection with exogenous HSV-1 cannot be excluded. This study aimed to determine the incidence of genital HSV-1 superinfection in patients by investigating the genotype of sequential HSV-1 isolates obtained from the same anatomical site of patients with clinical recurrences of genital HSV-1 recurrent genital herpes. Sequential genital HSV-1 isolates were genotyped by PCR amplification of the hypervariable regions located within the HSV-1 genes US1 and US12. Whereas the sequential HSV-1 isolates in 11 of the 13 patients studied had the same genotypes, the sequential isolates of 2 patients showed a different genotype. The data suggest that HSV-1-induced recurrent genital herpes can be associated with genital reinfection with an exogenous HSV-1 strain.

References

Mar 1, 1990·Journal of Clinical Microbiology·R BoomJ van der Noordaa
Aug 27, 1971·Science·J G Stevens, M L Cook
Jan 1, 1974·Intervirology·P SethJ L Melnick
Apr 1, 1984·The Journal of Infectious Diseases·O W SchmidtL Corey
Dec 1, 1994·Annals of Internal Medicine·J BenedettiR Ashley
Jun 16, 2000·The Journal of Antimicrobial Chemotherapy·D M Koelle, A Wald
Jan 12, 2001·Oral Microbiology and Immunology·B KnaupM H Wolff

❮ Previous
Next ❯

Citations

Jul 11, 2006·Journal of Clinical Microbiology·Emily Toth MartinAnna Wald
Dec 3, 2011·The Journal of Clinical Investigation·Christine JohnstonAnna Wald
Dec 3, 2011·The Journal of Clinical Investigation·Anne Rompalo
Sep 26, 2007·Retrovirology·Antoinette C van der Kuyl, Marion Cornelissen
Nov 13, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ilka EngelmannFrauke Mattner
Sep 24, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Peter Norberg
Dec 25, 2007·Lancet·Rachna GuptaAnna Wald
Jul 6, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kenichi UmeneTadamitsu Kameyama
Jun 20, 2013·Journal of Medical Virology·Monique van VelzenGeorges M G M Verjans
Feb 17, 2009·The Journal of General Virology·Jan Åke LiljeqvistPeter Norberg
Dec 18, 2013·Current Opinion in Infectious Diseases·Annika M HofstetterLawrence R Stanberry
Feb 5, 2016·Journal of Virology·A CriddleM P Taylor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.