Genotypic characterization of Neisseria meningitidis serogroup B strains circulating in China

The Journal of Infection
Li YangQi Jin

Abstract

In China, comparatively little research has been directed at serogroup B meningococci, which are mainly isolated from healthy individuals. We attempted to study the genotypic characterization of Neisseria meningitidis serogroup B strains. We analyzed 150 N. meningitidis strains isolated in China during 1975-2005 by multilocus sequence typing (MLST) and porA typing. A total of 88 different sequence types (STs) were identified by MLST, 73 of which were newly identified. Seven complexes previously identified in other countries and three unique clonal lineages first identified in China were detected, seven of which had previously been described as 'hyperinvasive meningococcal lineages'. Several lineages were found in specified period. A total of 63 different porA types were found, 11 of which were novel. The most common porA types were P1.5-1,2-2 (17 isolates), P1.5-1,10-4 (12 isolates), P1.5-2,2-2 (eight isolates) and P1.7-2,4 (seven isolates). In this context, serogroup B meningococci provide a diverse, continually reassorted gene pool from which new genotypes arise. The most important mechanism is probably horizontal genetic exchange among N. meningitidis serogroup B strains, possibly resulting in the emergence of new meningococ...Continue Reading

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Citations

Jan 20, 2009·Science in China. Series C, Life Sciences·RuiFu YangQingTian Li
Mar 28, 2009·The Journal of Infection·Li YangQi Jin
May 20, 2015·Emerging Infectious Diseases·Bingqing ZhuZhujun Shao
Jul 23, 2009·Current Opinion in Pediatrics

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