Genotypic distribution of human papillomavirus (HPV) and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs

Infectious Agents and Cancer
Nuttavut KantathavornArpaporn Arnamwong

Abstract

Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. A hospital-based cervical cancer screening program at Chulabhorn Hospital, Bangkok and a population-based screening program at a rural Pathum Thani Province were conducted using liquid-based cytology and HPV genotyping. Of 5906 women aged 20-70 years, Pap smear was abnormal in 4.9% and the overall HPV prevalence was 15.1%, with 6.4% high-risk (HR), 3.5% probable high-risk (PR), and 8.4% low-risk (LR) HPV. The prevalence and genotypic distribution were not significantly different between the two cohorts. Among HR-HPV genotypes, HPV52 was the most frequent (1.6%), followed by HPV16 (1.4%), HPV51 (0.9%), HPV58 (0.8%), HPV18 (0.6%), and HPV39 (0.6%). Among LR-HPV genotypes, HPV72 and HPV62 were the most frequent while HPV6 and HPV11 were rare. HPV infection was found to be proportionately high in young women, aged 20-30 years (25%) and decreasing with age (11% in women aged >50). The more severe abnormal cytology results, the higher positivity...Continue Reading

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Citations

Oct 25, 2016·Journal of Gynecologic Oncology·Sarikapan Wilailak, Nuttapong Lertchaipattanakul
Oct 8, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Sunila ShakyaSolveig Tingulstad
Jun 13, 2019·Oncology Letters·Daranee ChokchaichamnankitChantragan Srisomsap
Mar 9, 2017·Infectious Agents and Cancer·Cristina Artaza-IrigarayAdriana Aguilar-Lemarroy

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Datasets Mentioned

BETA
CP6108

Methods Mentioned

BETA
PCR
Genotyping

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