Genotypic linkages of gene segments of rotaviruses circulating in pediatric patients with acute gastroenteritis in Thailand

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Natthawan ChaimongkolN Maneekarn

Abstract

Rotavirus is a major cause of morbidity and mortality of infants and young children with diarrhea throughout the world. In Thailand, extensive studies of rotavirus infections have been reported continually and rotavirus diarrhea remains a common illness. To monitor the epidemiological situation of rotavirus in Chiang Mai, Thailand, surveillance of rotavirus circulating in pediatric patients was conducted. A total of 160 fecal specimens collected from children hospitalized with diarrhea were tested for rotaviruses groups A, B, and C by RT-PCR and their genotypes were identified by multiplex PCR and nucleotide sequencing. Group A rotavirus was detected at 29.4% but none of group B and C was found in this study. Molecular characterizations of G- and P-genotypes revealed three different G-P combinations, G1P[8] was the most predominant genotype with the prevalence of 72.3% followed by G2P[4] at 19.2%, and G3P[8] at 8.5%. Phylogenetic analyses of VP7 and VP4 genes of the representative strains detected in the present study, G1, G2, G3, and P[4] and P[8], respectively, revealed that G1 belonged to G1-Ic and G1-II, G2 belonged to G2-II, and G3 belonged to G3-III-S4 lineages while P[4] and P[8] were identified as P[4]-V and P[8]-III li...Continue Reading

References

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Citations

Jan 29, 2014·International Journal of Environmental Research and Public Health·Leera KittigulKannika Pombubpa
Feb 13, 2015·Virusdisease·Niwat Maneekarn, Pattara Khamrin
Dec 4, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A TheamboonlersY Poovorawan
Sep 17, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Renáta DóróKrisztián Bányai
Oct 28, 2017·Journal of Medical Virology·Wisoot Chan-It, Chulapong Chanta
Mar 28, 2019·The American Journal of Tropical Medicine and Hygiene·Pimmada SakpaisalCarl J Mason
May 30, 2020·Journal of Medical Virology·Jantawan SatayarakKobporn Boonnak

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