Abstract
Genotypic testing using TRUGENE was performed for treatment-naive, human immunodeficiency virus type 1 (HIV-1)-infected patients at baseline and after initiation of protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) regimens. The genetic diversity of HIV-1 pol sequences from 92 CRF01_AE and 21 B strains was compared. Subsequently, the impact of polymorphism on resistance to therapy was studied in CRF01_AE-infected (n=29) and subtype B-infected (n=14) patients. At baseline, the differences between CRF01_AE and B strain were mainly observed in the minor mutations L10I/V, M36I and L63P/I/H (P<0.001, chi(2)). In the reverse transcriptase sequence, M41L and T215Y/S were more common in patients infected with subtype B virus (P<0.05, chi(2)). Although all patients treated with PI-based HAART had pre-existing minor mutations, a low prevalence of resistance to PIs was observed (5/43; 11.6%). Moreover, major mutations (D30N and N88D) conferring resistance to PIs were found in patients infected with subtype B strain. In conclusion, polymorphisms at the protease region may not reduce PI susceptibility during treatment. However, this study also revealed the difference in natural mutations among subtypes, which may af...Continue Reading
References
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M Kimura
Jan 12, 2000·AIDS·H L DevereuxC Loveday
Sep 28, 2001·The Journal of Infectious Diseases·C F PernoUNKNOWN Italian Cohort Naive Antiretroviral (I.CO.N.A.) Study Group
Jul 31, 2002·Transfusion·John M JongeriusP Nico Lelie
Aug 27, 2002·The Journal of Infectious Diseases·Deenan PillayAbdel Babiker
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brigitte MontesMichel Segondy
Dec 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Li-Yang HsuNicholas I Paton
Aug 2, 2005·Lancet·Jonathan A C SterneUNKNOWN Swiss HIV Cohort Study
Mar 28, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Laurence VergneMartine Peeters
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA panel
Apr 3, 2007·Infection·C SukasemW Chantratita
Jun 14, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin S HirschDouglas D Richman
Jan 27, 2009·Infection·M M SantoroUNKNOWN CARe Study Group
Citations
Mar 12, 2011·The Protein Journal·Zhigang LiuLadislau C Kovari
Aug 19, 2011·The New England Journal of Medicine·Mark A WainbergBluma G Brenner
Dec 2, 2011·PloS One·Nicole Ngo-Giang-HuongUNKNOWN Program for HIV Prevention and Treatment (PHPT) study group
Feb 13, 2013·Drug Metabolism and Pharmacokinetics·Chonlaphat SukasemWeerawat Manosuthi
Feb 9, 2012·The Indian Journal of Medical Research·N KumarasamySanjay Pujari
Jul 14, 2012·Molecular Biology International·Mark A Wainberg, Bluma G Brenner
Dec 3, 2013·Infection·C SukasemS Sungkanuparph
Feb 26, 2009·The Kaohsiung Journal of Medical Sciences·Yu-Wen ChiuElla T Nkhoma
Aug 18, 2010·Microbes and Infection·Junko TanumaShinichi Oka
Jun 15, 2010·Journal of Molecular Graphics & Modelling·Rosemberg O SoaresMarcelo A Soares
Dec 25, 2012·Biochemical and Biophysical Research Communications·Zhigang LiuLadislau C Kovari
Jan 15, 2013·Biochemical and Biophysical Research Communications·Zhigang LiuLadislau C Kovari
Jul 12, 2013·ISRN Microbiology·Maria Mercedes Santoro, Carlo Federico Perno
Jan 31, 2014·Drug Metabolism and Pharmacokinetics·Chonlaphat SukasemWeerawat Manosuthi
Jul 2, 2009·Journal of the International AIDS Society·Jorge L Martinez-CajasMark A Wainberg
Feb 18, 2010·HIV Therapy·Philip A Chan, Rami Kantor
Dec 15, 2010·AIDS Research and Human Retroviruses·Fernando Flor-ParraPilar Pérez-Romero
Jun 9, 2009·AIDS Research and Human Retroviruses·Wattana AuwanitMasanori Kameoka
Jan 21, 2021·International Journal of Molecular Sciences·Paweł KowalczykIda Franiak-Pietryga