Genotyping and immunohistochemistry of gastrointestinal stromal tumors: An update

Seminars in Diagnostic Pathology
B P Rubin, Michael C Heinrich

Abstract

Gastrointestinal stromal tumors (GISTs) were originally thought to harbor either KIT or platelet-derived growth factor receptor A (PDGFRA) mutations only. However, more recent discoveries have highlighted additional, less common oncogenic driver mutations including NF1, BRAF, and succinate dehydrogenase (SDH) mutations. Genotyping GISTs has become more important since not all genotypes respond equally to FDA-approved tyrosine kinase inhibitors. GIST is a paradigm for personalized cancer therapy. Recent studies demonstrate how immunohistochemistry can be used both to diagnose GIST and to screen for specific mutations. DOG1 is particularly useful in the diagnosis of KIT-negative GIST, including tumors with PDGFRA mutations, which can also potentially be identified by immunohistochemistry for PDGFRA. SDHB immunohistochemistry is useful in characterizing GISTs with SDHA-D mutations, whereas SDHA immunohistochemistry is able to identify SDHA mutant GISTs.

References

Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Aug 3, 2005·Cancer Research·Brian P RubinJessica Woodell
Aug 13, 2005·The American Journal of Surgical Pathology·Johanna AnderssonLars-Gunnar Kindblom
Dec 20, 2005·Histopathology·B P Rubin
Apr 21, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria Debiec-RychterUNKNOWN Australasian GastroIntestinal Trials Group
Dec 30, 2006·Seminars in Diagnostic Pathology·Markku Miettinen, Jerzy Lasota
Jan 29, 2008·The American Journal of Surgical Pathology·Inigo EspinosaMatt van de Rijn
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Séverine Tabone-EglingerJean-François Emile
Jul 11, 2008·Genes, Chromosomes & Cancer·Narasimhan P AgaramCristina R Antonescu
Nov 7, 2008·The American Journal of Surgical Pathology·Jean-François EmileJean-Yves Blay
Apr 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pedro J Gomez-PinillaGianrico Farrugia
Dec 22, 2009·American Journal of Clinical Pathology·Isabelle HosteinJean-Michel Coindre
Oct 5, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·José GaalRonald R de Krijger
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Katherine A JanewayConstantine A Stratakis
Apr 5, 2011·Molecular Medicine Reports·Antonella BarrecaAchille Pich
Nov 18, 2011·Nature Reviews. Cancer·Christopher L CorlessMichael C Heinrich
Jun 30, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael C HeinrichMaria Debiec-Rychter
Sep 8, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew J WagnerJason L Hornick
Apr 20, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sebastian HussHans-Ulrich Schildhaus
Jun 14, 2013·Annals of Surgical Oncology·Piotr RutkowskiFrits van Coevorden
Jul 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jacqueline MaierNikolas von Bubnoff
May 27, 2014·Endocrine-related Cancer·Florian HallerAbbas Agaimy
Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ferga C GleesonMichael J Levy
Sep 23, 2014·BMC Cancer·Margherita NanniniMaria A Pantaleo
Apr 12, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Deanna D DaileyB E Powers
Sep 1, 2013·Surgical Pathology Clinics·Leona A Doyle, Jason L Hornick

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Citations

Sep 30, 2015·BMC Medical Genetics·Milena UrbiniMaria A Pantaleo
Jan 26, 2016·World Neurosurgery·Saksham GuptaIan F Dunn
Jul 3, 2015·International Journal of Surgical Pathology·Khin ThwayCyril Fisher
Dec 9, 2015·International Journal of Surgical Pathology·Wen NgKhin Thway
Apr 18, 2018·The British Journal of Surgery·W T A van der GraafJ H W de Wilt
Mar 20, 2020·Expert Review of Anticancer Therapy·Junaid ArshadJonathan C Trent
Aug 23, 2019·World Journal of Gastroenterology : WJG·Johanna WaidhauserBruno Märkl

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