Genotyping of varicella-zoster virus (vzv) wild-type strains isolated in the Czech Republic

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Vanda BostikovaPavel Bostik

Abstract

Monitoring of the varicella-zoster virus is becoming an important tool for analysis of the circulation of individual strains of VZV which differ not only at the genomic level, but show a variability in their clinical and epidemiological characteristics. Such data are not available on a large scale from the Czech population and could help understanding the epidemiological and evolutionary characteristics of the virus, as well as its potential for reinfection and increased pathogenesis in the population groups at higher risk for complications. The main aim of this study was detection and monitoring of wild-type or vaccine VZV strain isolates in the region of Eastern Bohemia and genotypic characterization of these isolates. A total of 273 clinical samples were obtained from patients exhibiting symptoms of varicella zoster virus (VZV) infection manifested as chickenpox or herpes zoster (HZ) treated in the Faculty Hospital of Charles University, Medical School in Hradec Kralove, Czech Republic. Characterization of individual short VZV DNA sequences was performed utilizing restriction fragment length polymorphisms (RFLPs), PCR and sequencing. Single nucleotide polymorphisms (SNP) in open reading frames (ORF) 21, 22 and 50 were used t...Continue Reading

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Citations

Jan 18, 2017·Central European Journal of Public Health·Vanda BoštíkováPavel Boštík
Apr 14, 2016·The Pediatric Infectious Disease Journal·Vanda BostikPavel Bostik

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