Gensenoside Rb1 protects rat PC12 cells from oxidative stress-induced endoplasmic reticulum stress: the involvement of thioredoxin-1

Molecular and Cellular Biochemistry
Xian-Si ZengLi-Fang Ma

Abstract

Oxidative stress plays an important role in many diseases and hydrogen peroxide (H2O2) plays a central role in the stress. Gensenoside Rb1 is the one of active ingredients in the traditional Chinese medicine Panax notoginseng. It has been reported that gensenoside Rb1 possesses various pharmacological activities. Here we report that gensenoside Rb1 exhibits potent protective effects against oxidative injury induced by H2O2 through inhibiting endoplasmic reticulum stress in PC12 cells. Cell viability assay demonstrated that incubation with H2O2 for 24 h led to a significant loss of cultured rat PC12 cells, and the cell viability was pronouncedly increased by pretreatment of gensenoside Rb1 for 24 h. H2O2-induced endoplasmic reticulum stress pathway was also suppressed after gensenoside Rb1 pretreatment, which was related with thioredoxin-1 (Trx-1) induction. Trx-1 siRNA abolished the protective effects of gensenoside Rb1. Our results of the present study demonstrate that gensenoside Rb1 shows a potent anti-oxidative effect on cultured PC12 cells by inducing Trx-1 expression.

References

Jul 18, 2003·Journal of Neuroscience Research·Zelan WeiXin-Min Li
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed
Jul 29, 2006·The Journal of Pharmacy and Pharmacology·T B Ng
Mar 1, 2012·Antioxidants & Redox Signaling·Aracely Garcia-GarciaRodrigo Franco
Apr 12, 2012·Human Molecular Genetics·Joo-Young ImM Maral Mouradian
Aug 7, 2012·Archives of Pharmacal Research·Jing LiChun-Su Yuan
Jan 19, 2013·Free Radical Biology & Medicine·Laurie H Sanders, J Timothy Greenamyre
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaotian SunOren A Levy
May 7, 2013·Progress in Neurobiology·Sudhakar Raja Subramaniam, Marie-Francoise Chesselet
Oct 9, 2013·Nature Reviews. Rheumatology·Andras Perl
Oct 22, 2013·Free Radical Biology & Medicine·Xian-Si ZengJie Bai
Nov 2, 2013·International Journal of Molecular Sciences·Dario PitoccoCarmine Cardillo
Nov 21, 2013·Journal of Parkinson's Disease·Vera DiasM Maral Mouradian
Jun 7, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaobin ZengRen Huang
Apr 4, 2015·Journal of Clinical Biochemistry and Nutrition·Hiroko P IndoHideyuki J Majima

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Citations

Aug 12, 2016·Cell Stress & Chaperones·Jin-Jing JiaXin-Qiang Song
Dec 31, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Lian JianChengzhi Lu
Mar 11, 2020·Frontiers in Pharmacology·Xian-Si ZengJin-Jing Jia
May 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ivo Ricardo de Seabra Rodrigues DiasLiang Liu

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