PMID: 9646360Jul 1, 1998Paper

Gentacoll hampers epithelialisation and neovascularisation in excisional wounds in hairless mice

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
K BangV E Hjortdal

Abstract

Our aim was to analyse the effect of Gentacoll on the rate of epithelialisation and neovascularisation in wound healing. Standardised circular full thickness dermal wounds 2.25 mm in diameter were created on the dorsum of each ear on 24 hairless homozygous mice (n = 48). The cartilaginous layer was left intact. The wounds were treated in a randomised blinded fashion with bovine collagen implants with gentamicin (Gentacoll) (n = 17); bovine collagen implants without gentamicin (n = 15); and Silicone film (n = 16). Epithelialisation and neovascularisation were measured directly by intravital video-microscopy and computerised planimetry immediately after the wounds had been made and every third day until the wounds closed. Only five of the wounds treated with Gentacoll (n = 17) epithelialised completely; and their mean (SEM) epithelialisation time was 22.8 (1.6) days, significantly longer than controls without gentamicin (n = 15) for which the corresponding figures were 14.5 (0.6) days. In nine wounds treated with Gentacoll the ear cartilage in the wound bed perforated and two wounds developed severe inflammation, which was followed by self-mutilation. Neovascularisation was incomplete in all of the wounds in the Gentacoll group, ...Continue Reading

References

Sep 1, 1977·Journal of Biomedical Materials Research·M Chvapil
Jan 1, 1976·International Journal of Dermatology·A J Sober
Dec 1, 1990·The Journal of Trauma·T K Hunt
Jun 1, 1989·Plastic and Reconstructive Surgery·J H BarkerK Messmer
Mar 1, 1994·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J H BarkerL J Weiner
Oct 1, 1995·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·M KimJ H Barker

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Citations

Dec 19, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Olaf KilianReinhard Schnettler
Mar 27, 2002·The Annals of Otology, Rhinology, and Laryngology·Ulla Friberg, Helge Rask-Andersen
Nov 4, 2020·Journal of Functional Biomaterials·Nunzia GalloLuca Salvatore

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