PMID: 7025734Jul 1, 1981Paper

Gentamicin assay: comparison of an adapted EMIT method and an RIA method

Annals of Clinical Biochemistry
J L Dols, A P van Zanten

Abstract

The EMIT technique for gentamicin assay adapted to the Centrifichem-300 system was compared with an established RIA procedure. EMIT results correlated very well with the results obtained by the RIA method (r = 0.976, N = 48). For the adapted EMIT assay, the interassay coefficient of variation was 4-8% and for the RIA method 6-14%. Several possible interfering agents were investigated, of which only carbenicillin showed interference in both assays. Our data indicate that the EMIT technique exhibits adequate precision and accuracy for routine gentamicin determinations.

References

Oct 1, 1978·Annals of Internal Medicine·G B Appel, H C Neu
Nov 3, 1978·JAMA : the Journal of the American Medical Association·J J SchentagM E Plaut
Jan 2, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Broughton, J E Strong
Nov 1, 1972·The Biochemical Journal·M J Healy
Oct 1, 1968·The Journal of Clinical Endocrinology and Metabolism·D RodbardG T Ross

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Citations

Jul 1, 1982·Annals of Clinical Biochemistry·L White

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