Gentamicin-attenuated Leishmania infantum: a clinicopathological study in dogs

Veterinary Immunology and Immunopathology
Hamid DaneshvarR Stephen Phillips

Abstract

The clinicopathological changes following infection with an attenuated line of Leishmania infantum (L. infantum H-line) were evaluated in mixed breed dogs. Two groups of dogs were infected intravenously (i.v.) or intradermally (i.d.) with L. infantum H-line and two control groups were infected i.v. or i.d. with L. infantum wild-type (L. infantum WT). None of the dogs, which were infected i.v. or i.d. with L. infantum H-line, showed any abnormalities during the observation period. In contrast, two out of three dogs, which were infected i.v. with L. infantum WT, developed clinical signs of disease. In addition, no histopathological changes were seen in the liver and spleen of the dogs infected with the attenuated line of parasite, whereas the histopathological changes in the two dogs infected i.v. with L. infantum WT were severe in form and manifested by infiltration of high numbers of inflammatory cells. No promastigotes were found in cultures set up from spleens and livers of dogs infected with L. infantum H-line at 12 months post-infection, whereas promastigotes were seen in the spleen and liver cultures from 2 dogs infected i.v. with L. infantum WT. Serum levels of total IgG anti-Leishmania antibody were raised in all dogs. T...Continue Reading

References

Oct 1, 1995·Veterinary Immunology and Immunopathology·A Martínez-MorenoS Hernández
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R D Pearson, A Q Sousa
Oct 16, 2002·Trends in Parasitology·Javier Moreno, Jorge Alvar
Dec 24, 2002·Infection and Immunity·Saeed AhmedDiane McMahon-Pratt
Jan 24, 2007·International Journal for Parasitology·Alhelí Rodríguez-CortésJordi Alberola

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