Abstract
The clinicopathological changes following infection with an attenuated line of Leishmania infantum (L. infantum H-line) were evaluated in mixed breed dogs. Two groups of dogs were infected intravenously (i.v.) or intradermally (i.d.) with L. infantum H-line and two control groups were infected i.v. or i.d. with L. infantum wild-type (L. infantum WT). None of the dogs, which were infected i.v. or i.d. with L. infantum H-line, showed any abnormalities during the observation period. In contrast, two out of three dogs, which were infected i.v. with L. infantum WT, developed clinical signs of disease. In addition, no histopathological changes were seen in the liver and spleen of the dogs infected with the attenuated line of parasite, whereas the histopathological changes in the two dogs infected i.v. with L. infantum WT were severe in form and manifested by infiltration of high numbers of inflammatory cells. No promastigotes were found in cultures set up from spleens and livers of dogs infected with L. infantum H-line at 12 months post-infection, whereas promastigotes were seen in the spleen and liver cultures from 2 dogs infected i.v. with L. infantum WT. Serum levels of total IgG anti-Leishmania antibody were raised in all dogs. T...Continue Reading
References
Oct 1, 1995·Veterinary Immunology and Immunopathology·A Martínez-MorenoS Hernández
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R D Pearson, A Q Sousa
Apr 6, 1999·Veterinary Parasitology·A RhalemB Berrag
Feb 7, 2001·Journal of Clinical Microbiology·L Solano-GallegoL Ferrer
Mar 10, 2001·Veterinary Parasitology·W L TafuriW L Tafuri
Apr 6, 2001·Parasitology·R J QuinnellC Dye
Nov 9, 2001·Acta Tropica·D SerenoJ L Lemesre
Oct 16, 2002·Trends in Parasitology·Javier Moreno, Jorge Alvar
Oct 29, 2002·The Journal of Infectious Diseases·Orin CourtenayChristopher Dye
Dec 24, 2002·Infection and Immunity·Saeed AhmedDiane McMahon-Pratt
Mar 2, 2005·Journal of Comparative Pathology·T RallisA F Koutinas
Mar 23, 2005·Vaccine·Jean-Loup LemesreGérard Papierok
Nov 29, 2005·Vaccine·Omar A SaldarriagaPeter C Melby
Jan 24, 2007·International Journal for Parasitology·Alhelí Rodríguez-CortésJordi Alberola
Jan 30, 2007·Veterinary Parasitology·M A B MoreiraM D Laurenti
Citations
Apr 20, 2014·PLoS Neglected Tropical Diseases·Hamid DaneshvarStephen Phillips
Oct 6, 2012·Parasitology·Hamid DaneshvarRichard Burchmore
Aug 11, 2010·Acta Tropica·Carla MaiaLenea Campino
Dec 14, 2011·Journal of Proteomics·Hamid DaneshvarRichard Burchmore
Apr 20, 2014·Frontiers in Immunology·Noushin SaljoughianSima Rafati
Nov 3, 2010·Parasite Immunology·H DaneshvarR Stephen Phillips
Mar 13, 2014·Parasite Immunology·H DaneshvarR Burchmore