Gentamicin concentrations in synovial fluid and joint tissues during intravenous administration or continuous intra-articular infusion of the tarsocrural joint of clinically normal horses

American Journal of Veterinary Research
Timothy B LescunStephen B Adams

Abstract

To compare gentamicin concentrations achieved in synovial fluid and joint tissues during IV administration and continuous intra-articular (IA) infusion of the tarsocrural joint in horses. 18 horses with clinically normal tarsocrural joints. Horses were assigned to 3 groups (6 horses/group) and administered gentamicin (6.6 mg/kg, IV, q 24 h for 4 days; group 1), a continuous IA infusion of gentamicin into the tarsocrural joint (50 mg/h for 73 hours; group 2), or both treatments (group 3). Serum, synovial fluid, and joint tissue samples were collected for measurement of gentamicin at various time points during and 73 hours after initiation of treatment. Gentamicin concentrations were compared by use of a Kruskal-Wallis ANOVA. At 73 hours, mean +/- SE gentamicin concentrations in synovial fluid, synovial membrane, joint capsule, subchondral bone, and collateral ligament of group 1 horses were 11.5 +/- 1.5 microg/mL, 21.1 +/- 3.0 microg/g, 17.1 +/- 1.4 microg/g, 9.8 +/- 2.0 microg/g, and 5.9 +/- 0.7 microg/g, respectively. Corresponding concentrations in group 2 horses were 458.7 +/- 130.3 microg/mL, 496.8 +/- 126.5 microg/g, 128.5 +/- 74.2 microg/g, 99.4 +/- 47.3 microg/g, and 13.5 +/- 7.6 microg/g, respectively. Gentamicin concen...Continue Reading

References

Sep 1, 1992·Veterinary Surgery : VS·K J WhithairD C Van Sickle
Sep 1, 1992·Antimicrobial Agents and Chemotherapy·M L BarclayS T Chambers
Jul 1, 1992·Veterinary Surgery : VS·K J WhitehairR P Bill
Jul 1, 1992·Veterinary Surgery : VS·K J WhitehairJ F Fessler
Nov 1, 1992·Equine Veterinary Journal·R K SchneiderA A Gabel
Aug 1, 1990·The Journal of Infectious Diseases·G L DaikosD M Livermore
Jul 2, 1988·The Veterinary Record·B S Brown, P J Timoney
Apr 1, 1987·The Veterinary Clinics of North America. Equine Practice·D C Hirsh, S S Jang
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M Alderson, S Nade
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D J Schurman, G Kajiyama
Jan 1, 1983·Equine Veterinary Journal·E C Firth
Apr 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·B H AndersonT Whittem
Jan 1, 1994·Equine Veterinary Journal·S SpiersG B Edwards
Dec 1, 1996·The Journal of Veterinary Medical Science·Y IzumisawaT Kotani
May 22, 1998·Journal of Veterinary Internal Medicine·P S Snyder
Apr 22, 1999·Journal of Veterinary Pharmacology and Therapeutics·E D MurpheyM G Papich
Apr 20, 2000·American Journal of Veterinary Research·T B LescunR P Bill
Mar 26, 2002·American Journal of Veterinary Research·Brad C ScheuchEugene P Steffey
Mar 19, 2004·Veterinary Surgery : VS·Shawn MattsonWilliam Black
Jul 1, 1997·Equine Veterinary Journal·J A Orsini, P Spencer

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Citations

Jun 21, 2006·Journal of the American Veterinary Medical Association·Timothy B LescunStephen B Adams
Mar 17, 2007·Research in Veterinary Science·P M TaylorS P L Luna
Apr 18, 2012·New Zealand Veterinary Journal·C L HerdanF E T Pauwels
Aug 18, 2020·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·Kajsa GustafssonGal Kelmer
Oct 26, 2020·Veterinary Medicine and Science·Adam RedpathIan Mark Bowen

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