PMID: 2097072Jan 1, 1990Paper

Gentamicin-induced chronotoxicity: use of body temperature as a circadian marker rhythm

Chronobiology International
G SoulbanA Yonovitz

Abstract

Aminoglycoside antibiotics produce varying degrees of ototoxicity, dependent on dosage time, in animals synchronized for rhythm study. Herein, we illustrate the use of an economical and reliable system to telemeter body temperature of laboratory animals as an endogenous marker rhythm for gentamicin-induced ototoxicity. Two groups of 3 male Sprague-Dawley rats (250-400 gm) were housed in separate cages in a temperature-controlled room programmed with a 12:12 LD schedule and monitored for hearing thresholds at the frequencies of 8kHz, 16 kHz, 24 kHz and 32 kHz at 2-week intervals. Each rat was dosed with 100 mg/kg/day gentamicin subcutaneously for a duration of 28 days. The animals from one group were dosed at their daily temperature maximum, while the animals of the other group were dosed at their daily temperature minimum. Both after 14 and 28 days of gentamicin treatment there was no important changes in auditory thresholds from baseline values when treatment was timed daily to the circadian peak of body temperature. Animals dosed daily at the trough of the circadian temperature rhythm evidenced an auditory threshold shift of between 5 and 25 dB after 14 days of treatment and a total hearing loss (80-90 dB) after 28 days of su...Continue Reading

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Citations

Sep 27, 2016·Hearing Research·Vasiliki BasinouBarbara Canlon
Aug 1, 1995·Disease-a-month : DM·M Kraft, R J Martin
Jul 1, 1997·Clinical Pharmacology and Therapeutics·J M PrinsP Speelman
Aug 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Evangelia TsergaBarbara Canlon
Jan 2, 2001·Acta Oto-laryngologica·G LaurellE Ferrary
Oct 29, 2020·Chronobiology International·Joshua E EronmoseleA B Olorukooba
Aug 21, 2021·American Journal of Audiology·Peter S Steyger

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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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