PMID: 696295Jul 1, 1978Paper

Gentamicin-induced mitochondrial damage in inner ear sensory cells of the lizard Calotes versicolor

Acta Oto-laryngologica
D Bagger-Sjöbäck, J Wersäll

Abstract

Earlier morphological and histochemical studies on the effects on inner ear sensory cells caused by aminoglycoside antibiotics have failed to give sufficient information of the genesis of these effects. The present study was focused on the phases of progessive mitochondrial changes in sensory cells of the the lizard basilar papilla induced by consecutive large doses of gentamicin. The mitochondria react by swelling, changes in the configuration and number of the cristae and formation of matrical inclusions. Myelin figures are a consistent finding in degenerating cells after gentamicin exposure. These are shown to be derived from changed mitochondria. The final product is an "onion-like" structure which is built of primitive membranes. There is a marked difference in reaction to the damage between individual mitochondria in the same cell. This difference is also evident between individual sensory cells in the same specimen. By studying the phases of the mitochondrial breakdown process in the sensory cell, some additional information on the changes in cell metabolism caused by ototoxic drugs, may be extracted.

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Citations

Jan 1, 1989·Archives of Oto-rhino-laryngology·M TakumidaD Bagger-Sjöbäck
Jan 1, 1984·The Journal of Laryngology and Otology·M Keene, J M Graham
Jun 23, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ulf-Rüdiger HeinrichWolf J Mann
Oct 1, 1977·Chemico-biological Interactions·M ThelestamR Möllby
Jan 1, 1991·Acta Oto-laryngologica·J C De GrootJ E Veldman
Aug 30, 2008·Mitochondrion·Young Geol Yoon, Michael D Koob
Jan 30, 2004·The Journal of Comparative Neurology·Keiko HiroseEdwin W Rubel
Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·E J LienL L Lien
Jan 31, 2013·Hearing Research·Erik C Böttger, Jochen Schacht
Aug 9, 2016·The Journal of Clinical Investigation·Robert EsterbergDavid W Raible
Nov 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G E Hyde, E W Rubel
Nov 5, 2003·American Journal of Veterinary Research·Keith G BensonArthur L Craigmill
Jan 13, 2019·Journal of the Association for Research in Otolaryngology : JARO·Sarah B Pickett, David W Raible

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