PMID: 8938845Nov 1, 1996Paper

Gentamicin-induced nephrotoxicosis in lambs

Research in Veterinary Science
A A Fadel, H A Larkin

Abstract

Lambs injected with gentamicin sulphate remained bright and continued to eat, but their plasma creatinine and urinary microprotein concentrations and activities of alkaline phosphatase, gamma glutamyltransferase, leucine aminopeptidase, and N-acetyl-beta-glucosaminidase were significantly increased. Urinary creatinine and specific gravity were significantly decreased. The kidneys of lambs killed shortly after the last treatment with gentamicin were pale and oedematous and microscopic changes included marked tubular necrosis and dilation. Mild tubular dilation was the only lesion in lambs killed later. Reduced enzyme activity was observed histochemically in cells of the convoluted tubules. The lambs showed little clinical evidence of gentamicin toxicity, but the urinary enzyme activity and protein content were sensitive and reliable markers of renal injury, in agreement with the pathological findings. The lesions were different from those reported in naturally occurring tubular nephrosis of lambs.

References

Apr 1, 1977·Journal of Comparative Pathology·M Robinson, J Trafford
Feb 18, 1989·The Veterinary Record·R A HoggD F Gibbons
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Jan 1, 1968·Nephron·R F Kempczinski, J B Caulfield
Mar 25, 1969·Journal of Chromatography·M WernerM Atoba

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Citations

Apr 5, 1997·The Veterinary Record·L K Cullen, J A Reynoldson
Feb 12, 2009·Development, Growth & Differentiation·Naoki WatanabeYuko Wakamatsu

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