Geobiology reveals how human kidney stones dissolve in vivo

Scientific Reports
Mayandi SivaguruBruce W Fouke

Abstract

More than 10% of the global human population is now afflicted with kidney stones, which are commonly associated with other significant health problems including diabetes, hypertension and obesity. Nearly 70% of these stones are primarily composed of calcium oxalate, a mineral previously assumed to be effectively insoluble within the kidney. This has limited currently available treatment options to painful passage and/or invasive surgical procedures. We analyze kidney stone thin sections with a combination of optical techniques, which include bright field, polarization, confocal and super-resolution nanometer-scale auto-fluorescence microscopy. Here we demonstrate using interdisciplinary geology and biology (geobiology) approaches that calcium oxalate stones undergo multiple events of dissolution as they crystallize and grow within the kidney. These observations open a fundamentally new paradigm for clinical approaches that include in vivo stone dissolution and identify high-frequency layering of organic matter and minerals as a template for biomineralization in natural and engineered settings.

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Citations

Jun 9, 2019·World Journal of Urology·Vincent De ConinckOlivier Traxer
Feb 19, 2020·Physical Chemistry Chemical Physics : PCCP·M ShanthilP K Sajith
May 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Thomas E RobinsonLiam M Grover
Nov 5, 2019·Nature Reviews. Urology·Mayandi SivaguruBruce W Fouke
Jun 4, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Federico MijangosEunate Arana
May 22, 2020·Urolithiasis·Norbert LaubeChristian Fisang
May 26, 2021·Nature Reviews. Urology·Mayandi SivaguruBruce W Fouke
Jan 19, 2021·ACS Biomaterials Science & Engineering·Sorout ShaliniAdam J Matzger
Oct 14, 2019·ACS Biomaterials Science & Engineering·Derek S FrankAdam J Matzger

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Methods Mentioned

BETA
super-resolution microscopy
scanning
x-ray spectroscopy
transmission electron microscopy

Software Mentioned

Adobe Photoshop
Zeiss Zen Blue Black
COM
Zen

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