Geochemical Continuity and Catalyst/Cofactor Replacement in the Emergence and Evolution of Life

Angewandte Chemie
Juan C Fontecilla-Camps

Abstract

The origin of life is mostly divided into "genetics first" and "metabolism first" hypotheses. The former is based on spark-tube tests and organic species from meteorites and comets, and proposes a heterotrophic origin of life also consistent with the "RNA World" concept. The "metabolism first" hypothesis posits that life began autotrophically on minerals and/or hydrothermal vents. The lack of direct evidence means it is not possible to lend solid support to either hypothesis but the "metabolism first" option can be explored if a continuous geochemical, catalytically dynamic process is assumed. Using this approach, it is speculated that purine and pyrimidine synthesis originated on a mineral surface, which was later replaced by ATP. The same applies to redox processes where metal-bound hydrides could have been replaced by NAD.

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Citations

Aug 2, 2019·PloS One·Oliver Vickman, Albert Erives
Apr 30, 2020·Biology·Jacques Demongeot, Alexandra Henrion-Caude
May 18, 2020·FEBS Letters·Andrey do Nascimento VieiraMartina Preiner
Nov 7, 2019·International Journal of Molecular Sciences·Vladimir Kubyshkin, Nediljko Budisa
Jan 16, 2021·Journal of Inorganic Biochemistry·Juan C Fontecilla-Camps
Jul 21, 2020·Chemical Reviews·Kamila B MuchowskaJoseph Moran
Sep 15, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Gary M C OngJianzhong Wu
Oct 1, 2021·Scientific Reports·Louis M P Ter-OvanessianMarie-Christine Maurel

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