Geoepidemiologic variation in outcomes of primary sclerosing cholangitis

World Journal of Hepatology
Tej I MehtaJames H Tabibian

Abstract

Primary sclerosing cholangitis (PSC) is a chronic, progressive, hepatobiliary disease characterized by inflammation and fibrosis of the intra- and extra-hepatic bile ducts. Its natural history is one that generally progresses towards cirrhosis, liver failure, cholangiocarcinoma, and ultimately disease-related death, with a median liver transplantation-free survival time of approximately 15-20 years. However, despite its lethal nature, PSC remains a heterogenous disease with significant variability in outcomes amongst different regions of the world. There are also many regions where the outcomes of PSC have not been studied, limiting the overall understanding of this disease worldwide. In this review, we present the geoepidemiologic variations in outcomes of PSC, with a focus on survival pre- and post-liver transplantation as well as the concurrence of inflammatory bowel disease and hepatobiliary neoplasia.

References

Jun 1, 1991·Gastroenterology·J M FarrantR Williams
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerN F LaRusso
Jan 1, 1988·Annals of Surgery·J W MarshT E Starzl
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BrooméL S Eriksson
Dec 1, 1994·Journal of Hepatology·E SchrumpfF Kolmannskog
May 1, 1996·Journal of Gastroenterology and Hepatology·R KochharJ B Dilawari
Oct 6, 2001·Journal of Clinical Gastroenterology·E ParlakB Sahin
Jun 29, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ivo W Graziadei
Aug 8, 2002·Journal of Gastroenterology and Hepatology·Tiing Leong AngJessica Yi-Lyn Tan
Oct 3, 2002·The American Journal of Gastroenterology·Kathy J HurlburtKris V Kowdley
Jan 25, 2003·Transplantation·Ulf P NeumannPeter Neuhaus
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marcelo KugelmasGregory T Everson
Jun 19, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hajime TakikawaYasuni Nakanuma
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Alireza MoayyeriMohsen Sadatsafavi
Feb 24, 2006·Seminars in Liver Disease·Kristian BjøroErik Schrumpf
Oct 14, 2006·The American Journal of Gastroenterology·Jens J W TischendorfPeter N Meier
Jan 24, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Sumihito TamuraMasatoshi Makuuchi
Apr 10, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Atsushi TanakaHajime Takikawa
Jun 9, 2009·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger ChapmanUNKNOWN American Association for the Study of Liver Diseases
Oct 30, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christopher L BowlusCarlo Selmi
Jan 12, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H EgawaH Tsubouchi
Jan 29, 2011·Journal of Crohn's & Colitis·Konstantinos H KatsanosUNKNOWN Northwest Greece IBD Study Group
Feb 26, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Natalie A MolodeckyGilaad G Kaplan
Aug 24, 2011·World Journal of Hepatology·Holger H Lutz, Jens Jw Tischendorf
Oct 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jing Hieng NguCatherine Ann Malcolm Stedman
Mar 21, 2012·Alimentary Pharmacology & Therapeutics·U NavaneethanR P Kiran
Apr 23, 2013·Journal of Hepatology·Tom H Karlsen, Kirsten Muri Boberg
May 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark DeneauStephen L Guthery
Jun 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kirsten BoonstraUNKNOWN EpiPSCPBC Study Group
Oct 30, 2013·Endoscopy·Laurent Peyrin-BirouletUNKNOWN IBD Committee of the French Society of Digestive Endoscopy
Mar 29, 2014·Interventional Medicine & Applied Science·Fanni GelleyBalázs Nemes
Sep 23, 2014·Journal of Hepatology·Jessica K DysonDavid E J Jones
Apr 15, 2015·The American Journal of Gastroenterology·Keith D LindorUNKNOWN American College of Gastroenterology
Jul 19, 2015·Journal of Hepatology·Reena RavikumarAndrew Burroughs
Dec 5, 2015·European Journal of Gastroenterology & Hepatology·Roberta E RossiSara Massironi
Jan 16, 2016·Pediatric Gastroenterology, Hepatology & Nutrition·Jisun YoonKyung Mo Kim

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Citations

Mar 9, 2021·Expert Review of Gastroenterology & Hepatology·Brian M Fung, James H Tabibian

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