journal cover

Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5

Vaccine

Feb 21, 2012

Kazuyuki TanabeToshihiro Horii

Get paper from

Abstract

SERA5 is regarded as a promising malaria vaccine candidate of the most virulent human malaria parasite Plasmodium falciparum. SERA5 is a 120 kDa abundantly expressed blood-stage protein containing a papain-like protease. Since substantial polymorphism in blood-stage vaccine candidates m...read more

Mentioned in this Paper

MAFK wt Allele
Genetic Analysis
DNA Sequence
Gene Flow
Amino Acid [EPC]
Proteolytic Enzyme
Amino Acid Substitution
Phosphoglycerate Dehydrogenase Activity
Signal Peptides
Genetic Equilibrium
Paper Details
References
  • References29
  • Citations12
123
  • References29
  • Citations12
12

Similar Papers Found In These Feeds

Dpp4, Pluritpotency & Cancer Cells

DPP4 has the potential to truncate proteins. DPP4-mediated truncation of certain chemokines, interleukins, and colony stimulating factors have recently been linked to regulation of hematopoietic stem/progenitor cells. Given its role in tumor biology, it is also used as a marker for various cancers. Here is the latest research.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Plasmodium Falciparum

Malaria remains a major cause of morbidity and mortality in the tropics, with the parasite Plasmodium falciparum responsible for the majority of the disease burden. Discover the latest research on Plasmodium falciparum.

Parasite Genetics

Parasite genetics is the study of the genetic material of parasites. Here is the latest research on parasite genetics.

Malaria

Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. Discover the latest research on malaria here,

Malaria Vaccines

Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Parasite Immune Evasion

Parasite immune evasion refers to the process by which parasites counteract the host immune system. Here is the latest research on mechanisms that underlie this evasion.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2019 Meta ULC. All rights reserved

Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5

Vaccine

Feb 21, 2012

Kazuyuki TanabeToshihiro Horii

PMID: 22230587

DOI: 10.1016/j.vaccine.2011.12.124

Abstract

SERA5 is regarded as a promising malaria vaccine candidate of the most virulent human malaria parasite Plasmodium falciparum. SERA5 is a 120 kDa abundantly expressed blood-stage protein containing a papain-like protease. Since substantial polymorphism in blood-stage vaccine candidates m...read more

Mentioned in this Paper

MAFK wt Allele
Genetic Analysis
DNA Sequence
Gene Flow
Amino Acid [EPC]

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References29
  • Citations12
123
  • References29
  • Citations12
12

Get paper from

/papers/geographic-differentiation-of-polymorphism-in-the/22230587