Geographic distribution of consanguinity in Europe

Annals of Human Biology
J M McCullough, D H O'Rourke

Abstract

Average consanguinity (alpha) of 20 large regional or national samples derived from Roman Catholic Dispensations or state archives shows a strong negative relationship with latitude (r = -0.738; P less than 0.001) which seems best explained by cultural-historical factors. Isolates show no such pattern and are more variable in their inbreeding levels. Two-way analysis of variance shows the sample division by population size to be significant, the division by geography to be not significant, with no significant interaction between the two factors. In a one-way analysis of variance only the mainstream samples showed significant geographic differences (P less than 0.001). There is no such geographic association in Japan which has greater cultural and historical homogeneity. The clinical patterning in average consanguinity may bias frequency estimates of rare alleles, including genetic disorders.

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Citations

Aug 22, 2012·Journal of Biosocial Science·Cathy Day, Malcolm Smith
Feb 15, 2008·International Journal of Epidemiology·Alun Evans
Jul 1, 1993·Annals of Human Biology·M T SmithC J Ellam
Feb 1, 1991·American Journal of Physical Anthropology·L B Jorde, K J Pitkänen
Nov 29, 2016·Annals of Human Biology·Mohd Fareed, Mohammad Afzal
Sep 4, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Vicente Fuster, Sonia Edith Colantonio
Apr 1, 1988·American Journal of Physical Anthropology·E O'BrienA W Eriksson
Sep 6, 2005·Annals of Human Genetics·A H Bittles, I Egerbladh
Apr 18, 2019·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Omar B SaeedJohn A van Aalst
Nov 1, 1992·Annals of Human Biology·M T SmithE M Cunha
Aug 21, 2002·Obstetrical & Gynecological Survey·Caroline M de Costa
Oct 27, 2004·American Journal of Physical Anthropology·Miguel A Alfonso-SánchezRosario Calderón

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