Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC

Scientific Reports
Yi FengYiming Shao

Abstract

To determine the origin and evolutionary history of two predominant and closely-related circulating recombinant forms (CRF07_BC and CRF08_BC), recombinant structures and phylogenies of 7 unique recombinant forms comprised of subtypes of B' (Thai B linage) and C (designated URFs_BC) from archival specimens of injection drug users (IDUs) collected in 1996 to 1998 from western Yunnan and 4 circulating recombinant forms with B'/C recombinants recently identified (designated nCRFs_BC) in China were compared with those of CRF07_BC and CRF08_BC. The results showed that 5 of 7 URFs_BC and all the nCRFs_BC shared recombination breakpoints with CRF07_BC and/or CRF08_BC. Yunnan URFs_BC consistently occupied the basal branch positions compared with CRF07_BC, CRF08_BC, and nCRFs_BC in phylogenetic trees. The estimated most recent common ancestors (tMRCA) for Yunnan URFs_BC were from ~1987, approximately half a decade earlier than those for CRF07_BC (~1994) and CRF08_BC (~1992). Discrete phylogeographic and spatial diffusion analysis revealed that both CRF07_BC and CRF08 BC came from western Yunnan in the early 1990s. Our results provide compelling evidence for western Yunnan as the geographic origin of CRF07_BC and CRF08_BC, which emerged f...Continue Reading

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Citations

Mar 17, 2017·AIDS Research and Human Retroviruses·Fan LiYiming Shao
Nov 22, 2016·Journal of Medical Virology·Adhikarimayum Lakhikumar SharmaLisam Shanjukumar Singh
May 11, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hong LuanHong Shang
Feb 15, 2018·AIDS Research and Human Retroviruses·Mengyan ZhangWenhui Chang
Aug 29, 2017·AIDS Research and Human Retroviruses·Mengyan ZhangWenhui Chang
Feb 23, 2019·AIDS Research and Human Retroviruses·Li WuYihua Kong
Jun 13, 2019·AIDS Research and Human Retroviruses·Mengyan ZhangWenhui Chang
Jan 31, 2020·Emerging Microbes & Infections·Tsz Ho KwanShui Shan Lee
Apr 11, 2020·Journal of Medical Virology·Wei LiPingmin Wei
Jul 25, 2017·International Journal of Environmental Research and Public Health·Peipei XiaoHaitao Yang
Jul 31, 2019·BMC Infectious Diseases·Min ChenManhong Jia
Sep 18, 2020·Journal of Virology·Bram VranckenAntoine Chaillon
Dec 15, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yun LanFengyu Hu
Sep 10, 2021·Emerging Microbes & Infections·Zhangwen GeYiming Shao
Nov 12, 2021·Chinese Medical Journal·Jun-Jie XuHong Shang

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Datasets Mentioned

BETA
KF250366-
KF250385

Methods Mentioned

BETA
genotyping

Software Mentioned

FigTree
SPREAD ( Spatial Phylogenetic Reconstruction of Evolutionary D...
Bootscan
Simplot
SPREAD
Gene Cutter
tMRCA
BioEdit
MEGA
BEAST

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