PMID: 16645446Apr 29, 2006Paper

Geographic regional differences in rocuronium bromide dose-response relation and time course of action: an overlooked factor in determining recommended dosage

Anesthesiology
Ashraf A DahabaHelfried Metzler

Abstract

Geographic location is not acknowledged as a stratifying factor that can directly affect drug potency, because drugs are still licensed with the same recommended dose for different geographic regions. The aim of the current study was to compare the potency and duration of action of rocuronium bromide in 54 patients in three countries with different life habits, diet, and ambient conditions, namely white Austrians, white North Americans, and Han Chinese in China. Neuromuscular block of six consecutive 50-microg/kg rocuronium incremental doses followed by 300 microg/kg was evaluated using the Relaxometer mechanomyograph (Groningen University, Groningen, Holland). Dose-response curves were created using log-dose-probit transformation. The authors compared rocuronium bromide ED50, ED90, and ED95 (effective doses required for 50%, 90%, and 95% first twitch depression, respectively) as well as Dur25 and Dur0.8 (times from last incremental dose administration until 25% first twitch and 0.8 train-of-four ratio recovery, respectively) in patients of the three countries. Rocuronium ED50, ED90, and ED95 were significantly higher in Austrian patients (258 +/- 68, 530 +/- 159, and 598 +/- 189 microg/kg) and Chinese patients (201 +/- 59, 413...Continue Reading

References

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Jan 1, 1996·Acta Anaesthesiologica Scandinavica·J Viby-MogensenD Ostergaard
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Citations

Jan 26, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ashraf A DahabaHelfried Metzler
Nov 12, 2010·British Journal of Anaesthesia·A F KopmanM Naguib
Jun 23, 2007·Anesthesiology·Tiberiu EzriShmuel Evron
Oct 6, 2016·Korean journal of anesthesiology·Jeong Ho KimSeung Cheol Lee
Oct 20, 2017·Korean journal of anesthesiology·Yong Beom KimHong Seuk Yang
Nov 28, 2017·Acta Anaesthesiologica Scandinavica·M FujimotoT Yamamoto
Mar 8, 2021·British Journal of Anaesthesia·Sirkku AhlströmEija Kalso
Aug 18, 2021·Brazilian Journal of Anesthesiology·Carlos Eduardo David de AlmeidaNorma Sueli Pinheiro Modolo

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